uracil transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. [GOC:go_curators]

Uracil transmembrane transporter activity is a molecular function that refers to the process by which proteins facilitate the movement of uracil across cell membranes. Uracil, a pyrimidine base found in RNA and DNA, is essential for the synthesis of nucleic acids and other vital biomolecules. Transporters play a crucial role in regulating uracil concentration within cells and between different compartments, ensuring adequate supply for cellular processes. Uracil transmembrane transporters typically function through a variety of mechanisms, including passive diffusion, facilitated diffusion, and active transport. Passive diffusion relies on the concentration gradient of uracil across the membrane, while facilitated diffusion involves carrier proteins that bind uracil and facilitate its movement down the concentration gradient. Active transport, in contrast, requires energy to move uracil against its concentration gradient. These transporters are highly specific for uracil and can distinguish it from other pyrimidines and nucleosides. They often exhibit complex regulation, responding to cellular signals and environmental cues to maintain proper uracil homeostasis. The activity of uracil transmembrane transporters is critical for various cellular functions, including nucleic acid synthesis, DNA repair, and nucleotide metabolism. Dysregulation of these transporters can lead to various pathological conditions, such as cancer and metabolic disorders.'
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Proteins (2)

Compounds (19)