Aldehyde dehydrogenase, dimeric NADP-preferring

An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30838]

EC 1.2.1.5;
ALDHIII;
Aldehyde dehydrogenase 3;
Aldehyde dehydrogenase family 3 member A1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-(diethylamino)benzaldehyde	Homo sapiens (human)	IC50	5.6700	1	1
1-(4-chlorophenyl)sulfonyl-2-benzimidazolamine	Homo sapiens (human)	IC50	1.2000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-nitrobenzaldehyde	Homo sapiens (human)	Km	31.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
aldehyde dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. [EC:1.2.1.3]
aldehyde dehydrogenase [NAD(P)+] activity	molecular function	Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. [EC:1.2.1.5]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
alcohol dehydrogenase (NADP+) activity	molecular function	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. [EC:1.1.1.2]
benzaldehyde dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. [EC:1.2.1.28]
3-chloroallyl aldehyde dehydrogenase activity	molecular function	Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. [UM-BBD_enzymeID:e0432]

This protein is located in 4 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 3 target(s):

Target	Category	Definition
cellular aldehyde metabolic process	biological process	The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. [GOC:go_curators, ISBN:0198506732]
lipid metabolic process	biological process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]