Page last updated: 2024-10-06
superpathway of methionine degradation
Proteins (19)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| S-adenosylmethionine synthase isoform type-1 | AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III | Homo sapiens (human) |
| Adenosylhomocysteinase | AdoHcyase; EC 3.3.1.1; S-adenosyl-L-homocysteine hydrolase | Homo sapiens (human) |
| Propionyl-CoA carboxylase alpha chain, mitochondrial | PCCase subunit alpha; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit alpha | Homo sapiens (human) |
| Propionyl-CoA carboxylase beta chain, mitochondrial | PCCase subunit beta; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit beta | Homo sapiens (human) |
| S-methylmethionine--homocysteine S-methyltransferase BHMT2 | SMM-hcy methyltransferase; EC 2.1.1.10; Betaine--homocysteine S-methyltransferase 2 | Homo sapiens (human) |
| Aspartate aminotransferase, cytoplasmic | cAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A | Homo sapiens (human) |
| S-adenosylmethionine synthase isoform type-2 | AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II | Homo sapiens (human) |
| Betaine--homocysteine S-methyltransferase 1 | EC 2.1.1.5 | Homo sapiens (human) |
| Cystathionine beta-synthase | EC 4.2.1.22; Beta-thionase; Serine sulfhydrase | Homo sapiens (human) |
| Methionine synthase | MS; EC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase | Homo sapiens (human) |
| Cysteine dioxygenase type 1 | EC 1.13.11.20; Cysteine dioxygenase type I; CDO; CDO-I | Homo sapiens (human) |
| Methylmalonyl-CoA epimerase, mitochondrial | EC 5.1.99.1; DL-methylmalonyl-CoA racemase | Homo sapiens (human) |
| Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | EC 2.3.1.168; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis; Branched chain 2-oxo-acid dehydrogenase complex component E2; BCOADC-E2; Branched-chain alpha-keto acid dehydrogenase complex component E2; BCKAD-E2; BCKADE2; Dihydrolipoamide ac | Homo sapiens (human) |
| Dihydrolipoyl dehydrogenase, mitochondrial | EC 1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein | Homo sapiens (human) |
| Sulfite oxidase, mitochondrial | EC 1.8.3.1 | Homo sapiens (human) |
| Methylmalonyl-CoA mutase, mitochondrial | MCM; EC 5.4.99.2; Methylmalonyl-CoA isomerase | Homo sapiens (human) |
| 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | EC 1.2.4.4; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha | Homo sapiens (human) |
| 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | EC 1.2.4.4; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta | Homo sapiens (human) |
| Methionine adenosyltransferase 2 subunit beta | Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase | Homo sapiens (human) |
Compounds (28)
| Compound | Description |
|---|---|
| diphosphoric acid | |
| hydronium ion | |
| Molybdenum | A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. |
| NADH | |
| Ammonium | |
| betaine | A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341) |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Orthophosphate | |
| adenosine | A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| hydrogen carbonate | |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| succinyl-coenzyme A | |
| Pyruvic Acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| sulfites | Inorganic salts of sulfurous acid. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| alpha-Ketoglutarate | |
| 2-ketobutyrate | |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Cysteine | A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. |
| Vitamin U | A vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract. |
| cysteine sulfinate | |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| propionyl-coenzyme A | RN given refers to parent cpd |