Compounds > vx-745
Page last updated: 2024-09-05

vx-745 and dactolisib

vx-745 has been researched along with dactolisib in 3 studies

Compound Research Comparison

Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010)
(vx-745)		Studies
(dactolisib)		Trials
(dactolisib)		Recent Studies (post-2010) (dactolisib)
5813544414405

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)dactolisib (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformRattus norvegicus (Norway rat)0.0053
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0692
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaHomo sapiens (human)0.034
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)0.044
Bile salt export pumpHomo sapiens (human)7.9
Cytochrome P450 1A2Homo sapiens (human)0.079
Cytochrome P450 2D6Homo sapiens (human)0.079
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.1532
Cytochrome P450 2C19Homo sapiens (human)0.014
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.0267
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.3474
Serine/threonine-protein kinase mTORHomo sapiens (human)0.0233
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.1022
Tyrosine-protein kinase JAK3Homo sapiens (human)1
Serine-protein kinase ATMHomo sapiens (human)0.007
Regulatory-associated protein of mTORHomo sapiens (human)0.044
Phosphatidylinositol 3-kinase catalytic subunit type 3Homo sapiens (human)0.45
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.1205
Target of rapamycin complex subunit LST8Homo sapiens (human)0.044
Histone deacetylase 6Homo sapiens (human)0.002
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformRattus norvegicus (Norway rat)0.01

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Cahya, S; Cummins, DJ; Gao, C; Iversen, PW; Nicolaou, CA; Vieth, M; Wang, J; Watson, IA1

Other Studies

3 other study(ies) available for vx-745 and dactolisib

ArticleYear
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Selectivity data: assessment, predictions, concordance, and implications.
    Journal of medicinal chemistry, 2013, Sep-12, Volume: 56, Issue:17

    Topics: Computer Simulation; Drug Discovery

2013