Page last updated: 2024-09-02

r 56865 and ouabain

r 56865 has been researched along with ouabain in 13 studies

Compound Research Comparison

Studies
(r 56865)
Trials
(r 56865)
Recent Studies (post-2010)
(r 56865)
Studies
(ouabain)
Trials
(ouabain)
Recent Studies (post-2010) (ouabain)
721016,35772747

Protein Interaction Comparison

ProteinTaxonomyr 56865 (IC50)ouabain (IC50)
STAT3, partialHomo sapiens (human)1.154
Kruppel-like factor 5Homo sapiens (human)0.0832
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Norway rat)4.3
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.17
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.031
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)1.1263
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.1646
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.097
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)6
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)5.8
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-3Rattus norvegicus (Norway rat)0.0018
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0031

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19902 (15.38)18.7374
1990's10 (76.92)18.2507
2000's1 (7.69)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Frankow, C; Peters, T; Tegtmeier, F; Thoné, F; Vandeplassche, L; Wilhelm, D1
Heers, C; Peters, T; Scheufler, E; Wermelskirchen, D; Wilffert, B; Wilhelm, D1
Beile, A; Guttmann, I; Osikowska-Evers, B; Peters, T; Scheufler, E; Tegtmeier, F; Urenjak, J; Wilffert, B1
Borgers, M; Ver Donck, L1
Peters, T; Scheufler, E; Wilhelm, D1
Damiano, BP; Stump, GL; Yagel, SK1
Bravo, G; Finet, M; Godfraind, T1
Janssen, PA; Meuter, C; Vollmer, B1
Gorgels, AP; Leunissen, JD; van Deursen, RT; Vos, MA; Wellens, HJ1
Heers, C; Peters, T; Pierce, GN; Scheufler, E; Wilffert, B1
De Clerck, F; Lu, HR; Remeysen, P1
De la Fuente, MT; Esquerro, E; García, AG; Maroto, R; Sánchez-García, P1
Clanachan, AS; Lopaschuk, GD; Wang, L1

Other Studies

13 other study(ies) available for r 56865 and ouabain

ArticleYear
Effects of R 56865 and phenytoin on mechanical, biochemical, and morphologic changes during ouabain intoxication in isolated perfused rabbit heart.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:3

    Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Heart; In Vitro Techniques; Lactates; Male; Mitochondria, Heart; Myocardial Contraction; Myocardium; Ouabain; Oxygen Consumption; Phenytoin; Phosphorylation; Piperidines; Rabbits; Thiazoles; Ventricular Function, Left

1992
Differential effect of R 56865 on ouabain binding to isolated sarcolemma and intact atrial tissue of guinea-pig.
    British journal of pharmacology, 1991, Volume: 102, Issue:3

    Topics: Animals; Benzothiazoles; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles

1991
Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865.
    Neuropharmacology, 1992, Volume: 31, Issue:5

    Topics: Animals; Benzothiazoles; Brain Ischemia; Calcium; Disease Models, Animal; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles

1992
Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology.
    The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2

    Topics: Animals; Benzothiazoles; Calcium; Cardiomyopathies; Heart; Lysophosphatidylcholines; Myocardial Contraction; Ouabain; Oxygen; Piperidines; Rabbits; Rats; Singlet Oxygen; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine

1991
Differential influence of various calcium-modulating compounds on ouabain intoxication in isolated rat left atria.
    Pharmacology, 1990, Volume: 41, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Atrial Function, Left; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Heart; Heart Atria; Intracellular Fluid; Male; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Sodium; Thiazoles

1990
Investigation of electrophysiologic mechanisms for the antiarrhythmic actions of R 56865 in cardiac glycoside toxicity.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzothiazoles; Blood Pressure; Cardiac Glycosides; Dogs; Electrophysiology; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Ouabain; Papillary Muscles; Piperidines; Purkinje Fibers; Refractory Period, Electrophysiological; Thiazoles

1991
The protective action of R56865 against ouabain-induced intoxication in rat heart isolated atria and ventricles.
    European journal of pharmacology, 1989, May-30, Volume: 164, Issue:3

    Topics: Animals; Benzothiazoles; Biological Transport, Active; Electric Stimulation; Erythrocytes; Heart; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Piperidines; Rats; Rats, Inbred Strains; Sodium; Thiazoles

1989
R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.
    European journal of pharmacology, 1987, Oct-06, Volume: 142, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Ouabain; Papillary Muscles; Piperidines; Thiazoles

1987
R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner.
    Cardiovascular research, 1993, Volume: 27, Issue:8

    Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Ouabain; Piperidines; Tachycardia; Thiazoles

1993
Interference of N-(1-[4-(4-fluorophenoxy)butyl]-piperidinyl)-N-methyl- 2-benzothiazolamine with Na+/H+ exchange and Na+/Ca2+ exchange in purified cardiac sarcolemmal membranes.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:11

    Topics: Amiloride; Animals; Benzothiazoles; Calcium; Cattle; Heart; Hydrogen; In Vitro Techniques; Ion Exchange; Membranes; Myocardial Reperfusion; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Thiazoles

1993
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.
    European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil

1993
The actions of ouabain and lithium chloride on cytosolic Ca2+ in single chromaffin cells.
    European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3

    Topics: Adrenal Glands; Animals; Antimanic Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Enzyme Inhibitors; Lithium Chloride; omega-Conotoxins; Ouabain; Peptides; Piperidines; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Veratridine

1996
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.
    Journal of molecular and cellular cardiology, 2008, Volume: 45, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cnidarian Venoms; Hydrogen Peroxide; Ion Transport; Lidocaine; Male; Myocardial Reperfusion Injury; Myocardium; Organ Culture Techniques; Ouabain; Oxidants; Piperidines; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left

2008