Page last updated: 2024-09-05

ibogaine and cocaine

ibogaine has been researched along with cocaine in 39 studies

Compound Research Comparison

Studies (ibogaine)	Trials (ibogaine)	Recent Studies (post-2010) (ibogaine)	Studies (cocaine)	Trials (cocaine)	Recent Studies (post-2010) (cocaine)
445	8	136	32,461	1,096	9,400

Protein Interaction Comparison

Protein	Taxonomy	cocaine (IC50)
Amyloid-beta precursor protein	Homo sapiens (human)	0.338
Fatty acid-binding protein, heart	Homo sapiens (human)	0.367
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	0.0855
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	0.0855
D	Rattus norvegicus (Norway rat)	5.7544
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	5.7544
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	5.7544
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	5.7544
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	1.2861
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	0.4321
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	0.0855
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.5442
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.8885
Sodium-dependent dopamine transporter	Homo sapiens (human)	0.3796
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	5.541
Sodium-dependent dopamine transporter	Mus musculus (house mouse)	0.2
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	1.05
Transporter	Rattus norvegicus (Norway rat)	3.2277

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	23 (58.97)	18.2507
2000's	12 (30.77)	29.6817
2010's	4 (10.26)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Harsing, L; Hashim, A; Lajtha, A; Sershen, H	1
Glick, SD; Maisonneuve, IM	2
Hashim, A; Lajtha, A; Sershen, H	5
Dworkin, SI; Gleeson, S; Koves, TR; Martin, TJ; Meloni, D	1
Carlson, JN; Glick, SD; Keller, RW; Kuehne, ME; Larson, D; Raucci, J; Wilson, TE	1
Broderick, PA; Eng, F; Phelan, FT; Wechsler, RT	1
Schechter, MD	1
Cappendijk, SL; Dzoljic, MR	1
Bandarage, UK; Glick, SD; Kuehne, ME; Maisonneuve, IM; Molinari, HH	1
Ali, SF; Dillon, K; French, ED	1
Bandarage, UK; Glick, SD; Kuehne, ME; Maisonneuve, IM; Mann, GL; Visker, KE	1
Glick, SD; Maisonneuve, IS	1
Ali, SF; Chakrabarti, A; Onaivi, ES	1
Alburges, ME; Hanson, GR	2
Glick, SD; Maisonneuve, IM; Szumlinski, KK	5
Alburges, ME; Bush, L; Hanson, GR; Ramos, BP	1
Glick, SD; Maisonneuve, IM; McCafferty, CA; Szumlinski, KK	1
Ali, SF; Beaudoin, MA; Binienda, Z; Sadovova, N; Skinner, RD; Slikker, W; Thorn, BT	1
Ervin, FD; Kovera, CA; Mash, DC; Mayor, M; Pablo, J; Singleton, EG; Tyndale, RF; Williams, IC	1
Akinshola, BE; Ali, SF; Onaivi, ES	1
Campbell, SD; Jacobs, MT; Rudnick, G; Zhang, YW	1
Glick, SD; McCallum, SE	1
Forrest, LR; Rudnick, G; Tavoulari, S	1
Glick, SD; Polston, JE; Pritchett, CE; Sell, EM	1
Autzen, HE; Grouleff, J; Koldsø, H; Schiøtt, B	1
Rudnick, G; Turk, BE; Zhang, YW	1
de Moura, FB; McMahon, LR	1

Reviews

5 review(s) available for ibogaine and cocaine

Article	Year
Ibogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptors. Brain research bulletin, 1997, Volume: 42, Issue:3 Topics: Animals; Cocaine; Humans; Ibogaine; Receptors, Dopamine; Receptors, Serotonin; Substance-Related Disorders	1997
Mechanisms of antiaddictive actions of ibogaine. Annals of the New York Academy of Sciences, 1998, May-30, Volume: 844 Topics: Animals; Cocaine; Female; Ibogaine; Morphine; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Tobacco Use Disorder	1998
In vivo ibogaine blockade and in vitro PKC action of cocaine. Annals of the New York Academy of Sciences, 1998, May-30, Volume: 844 Topics: Animals; Avoidance Learning; Cocaine; Humans; Ibogaine; Isoenzymes; Maze Learning; Mice; Mice, Inbred ICR; PC12 Cells; Protein Kinase C; Rats	1998
Changes in gene expression and signal transduction following ibogaine treatment. The Alkaloids. Chemistry and biology, 2001, Volume: 56 Topics: Animals; Calcium; Cocaine; Gene Expression Regulation; Humans; Ibogaine; Nucleus Accumbens; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Signal Transduction; Substance-Related Disorders	2001
Mechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener. The Alkaloids. Chemistry and biology, 2001, Volume: 56 Topics: Animals; Behavior, Animal; Cocaine; Humans; Ibogaine; Morphine; Motor Activity; Self Administration	2001

Trials

1 trial(s) available for ibogaine and cocaine

Article	Year
Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: Adult; Cocaine; Depression; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Ibogaine; Male; Narcotics; Substance-Related Disorders; Surveys and Questionnaires; Time Factors	2000

Other Studies

33 other study(ies) available for ibogaine and cocaine

Article	Year
Ibogaine antagonizes cocaine-induced locomotor stimulation in mice. Life sciences, 1992, Volume: 50, Issue:15 Topics: Amphetamine; Animals; Biogenic Amines; Brain; Cocaine; Drug Administration Schedule; Ibogaine; Male; Mice; Mice, Inbred C57BL; Motor Activity	1992
Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior. European journal of pharmacology, 1992, Mar-03, Volume: 212, Issue:2-3 Topics: Animals; Cocaine; Dialysis; Dopamine; Drug Synergism; Female; Ibogaine; Motor Activity; Rats; Rats, Inbred Strains	1992
The effect of ibogaine on kappa-opioid- and 5-HT3-induced changes in stimulation-evoked dopamine release in vitro from striatum of C57BL/6By mice. Brain research bulletin, 1995, Volume: 36, Issue:6 Topics: Animals; Biguanides; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Ibogaine; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Serotonin	1995
Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats. Psychopharmacology, 1995, Volume: 117, Issue:3 Topics: Animals; Cocaine; Conditioning, Operant; Food; Heroin; Ibogaine; Male; Rats; Rats, Inbred F344; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	1995
Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain research, 1994, Sep-19, Volume: 657, Issue:1-2 Topics: Alkaloids; Animals; Cocaine; Corpus Striatum; Dopamine; Female; Harmaline; Ibogaine; Microdialysis; Morphine Dependence; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Tremor	1994
Ibogaine modulates cocaine responses which are altered due to environmental habituation: in vivo microvoltammetric and behavioral studies. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3 Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Dopamine; Electrochemistry; Environment; Habituation, Psychophysiologic; Ibogaine; Male; Microelectrodes; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior	1994
Cocaine discrimination is attenuated by isradipine and CGS 10746B. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3 Topics: Animals; Antipsychotic Agents; Calcium Channel Blockers; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Ibogaine; Isradipine; Male; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Thiazepines; Tropanes	1993
Ibogaine reduces preference for cocaine consumption in C57BL/6By mice. Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:1 Topics: Animals; Brain; Cocaine; Drinking; Ibogaine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Stereotyped Behavior; Substance-Related Disorders	1994
Inhibitory effects of ibogaine on cocaine self-administration in rats. European journal of pharmacology, 1993, Sep-14, Volume: 241, Issue:2-3 Topics: Analysis of Variance; Animals; Brain; Cocaine; Disease Models, Animal; Drug Administration Schedule; Ibogaine; Male; Motor Activity; Rats; Rats, Wistar; Self Administration; Substance-Related Disorders	1993
18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain research, 1996, May-06, Volume: 719, Issue:1-2 Topics: Animals; Cerebellum; Cocaine; Dopamine; Female; Ibogaine; Limbic System; Morphine; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Self Administration; Tremor	1996
Effect of ibogaine on cocaine-induced efflux of [3H] dopamine and [3H] serotonin from mouse striatum. Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Cocaine; Dopamine; Ibogaine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Narcotics; Neostriatum; Propranolol; Quinoxalines; Receptors, Opioid, kappa; Serotonin; Serotonin Receptor Agonists	1996
Effects of ibogaine, and cocaine and morphine after ibogaine, on ventral tegmental dopamine neurons. Life sciences, 1996, Volume: 59, Issue:12 Topics: Animals; Cocaine; Dopamine; Ibogaine; Morphine; Neurons; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area	1996
Time-dependent interactions between iboga agents and cocaine. European journal of pharmacology, 1997, Oct-08, Volume: 336, Issue:2-3 Topics: Animals; Cocaine; Drug Interactions; Female; Ibogaine; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Time Factors	1997
The Neurochemistry of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines. Proceedings of a meeting. Hamilton, Bermuda, July 16-18, 1997. Annals of the New York Academy of Sciences, 1998, May-30, Volume: 844 Topics: Amphetamines; Animals; Brain; Cocaine; Humans; Ibogaine; Neurochemistry; Substance-Related Disorders	1998
Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines. Proceedings of a conference. Niigata City, Japan, June 29-30, 1995. Annals of the New York Academy of Sciences, 1996, Oct-31, Volume: 801 Topics: Amphetamines; Animals; Central Nervous System; Cocaine; Humans; Ibogaine; Substance-Related Disorders	1996
Gender differences in kappa-opioid modulation of cocaine-induced behavior and NMDA-evoked dopamine release. Brain research, 1998, Aug-10, Volume: 801, Issue:1-2 Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Culture Techniques; Dopamine; Drug Administration Schedule; Female; Ibogaine; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Perfusion; Pyrrolidines; Receptors, Opioid, kappa; Sex Factors	1998
Differential responses by neurotensin systems in extrapyramidal and limbic structures to ibogaine and cocaine. Brain research, 1999, Feb-06, Volume: 818, Issue:1 Topics: Animals; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Ibogaine; Limbic System; Male; Neurotensin; Psychotropic Drugs; Rats; Rats, Sprague-Dawley	1999
Ibogaine enhances the expression of locomotor sensitization in rats chronically treated with cocaine. Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:3 Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Drug Tolerance; Female; Hallucinogens; Ibogaine; Motor Activity; Rats; Rats, Long-Evans; Stimulation, Chemical; Time Factors	1999
Pretreatment with the putative anti-addictive drug, ibogaine, increases the potency of cocaine to elicit locomotor responding: a study with acute and chronic cocaine-treated rats. Psychopharmacology, 1999, Volume: 145, Issue:2 Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Ibogaine; Motor Activity; Rats; Rats, Sprague-Dawley	1999
Ibogaine pretreatment dramatically enhances the dynorphin response to cocaine. Brain research, 1999, Nov-13, Volume: 847, Issue:1 Topics: Animals; Brain Chemistry; Cocaine; Dopamine Uptake Inhibitors; Dynorphins; Excitatory Amino Acid Antagonists; Ibogaine; Male; Neostriatum; Neural Pathways; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substantia Nigra	1999
Responses of the extrapyramidal and limbic substance P systems to ibogaine and cocaine treatments. European journal of pharmacology, 2000, Feb-25, Volume: 390, Issue:1-2 Topics: Animals; Cocaine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Ibogaine; Immunohistochemistry; Injections, Intraperitoneal; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substance P	2000
Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. European journal of pharmacology, 2000, Jun-16, Volume: 398, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catecholamines; Cocaine; Dopamine; Female; Homovanillic Acid; Ibogaine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stereotyped Behavior	2000
Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization. Brain research, 2000, Jul-21, Volume: 871, Issue:2 Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Ibogaine; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stereotyped Behavior	2000
Development of novel medications for drug addiction. The legacy of an African shrub. Annals of the New York Academy of Sciences, 2000, Volume: 909 Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Ibogaine; Morphine; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders	2000
18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ibogaine; In Vitro Techniques; Morphine; Psychopharmacology; Self Administration; Substance Withdrawal Syndrome	2000
Application of electrophysiological method to study interactions between ibogaine and cocaine. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Brain Chemistry; Cerebral Cortex; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Homovanillic Acid; Hydroxyindoleacetic Acid; Ibogaine; Male; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Wakefulness	2000
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. The Journal of biological chemistry, 2007, Oct-05, Volume: 282, Issue:40 Topics: Animals; Binding, Competitive; Cocaine; Cytoplasm; Excitatory Amino Acid Antagonists; HeLa Cells; Humans; Ibogaine; Kinetics; Plant Extracts; Protein Binding; Rats; Serotonin	2007
18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference. Neuroscience letters, 2009, Jul-17, Volume: 458, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Extinction, Psychological; Ibogaine; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Time Factors	2009
Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-29, Volume: 29, Issue:30 Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Chlorides; Cocaine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Ibogaine; Imipramine; Models, Chemical; Mutation; Protein Conformation; Protein Stability; Rats; RNA-Binding Proteins	2009
18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats. Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:1 Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Conditioning, Operant; Cues; Dopamine; Drug-Seeking Behavior; Female; Humans; Ibogaine; Music; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Administration	2012
Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations. PloS one, 2013, Volume: 8, Issue:6 Topics: Cocaine; Humans; Ibogaine; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins	2013
Control of serotonin transporter phosphorylation by conformational state. Proceedings of the National Academy of Sciences of the United States of America, 2016, May-17, Volume: 113, Issue:20 Topics: Biological Transport; Cocaine; Cyclic GMP-Dependent Protein Kinases; HeLa Cells; Humans; Ibogaine; Phosphorylation; Protein Conformation, alpha-Helical; Protein Processing, Post-Translational; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction	2016
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice. Psychopharmacology, 2017, Volume: 234, Issue:5 Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline	2017