deferasirox and itraconazole
deferasirox has been researched along with itraconazole in 4 studies
Compound Research Comparison
Studies (deferasirox) | Trials (deferasirox) | Recent Studies (post-2010) (deferasirox) | Studies (itraconazole) | Trials (itraconazole) | Recent Studies (post-2010) (itraconazole) |
---|---|---|---|---|---|
832 | 136 | 572 | 249 | 4 | 108 |
832 | 136 | 572 | 6,440 | 653 | 2,357 |
Protein Interaction Comparison
Protein | Taxonomy | deferasirox (IC50) | itraconazole (IC50) |
---|---|---|---|
Tyrosine-protein kinase Fyn | Homo sapiens (human) | 3.89 | |
ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 0.7 | |
ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.666 | |
Cytochrome P450 3A4 | Homo sapiens (human) | 0.4256 | |
ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 0.2 | |
C-X-C chemokine receptor type 1 | Homo sapiens (human) | 2.5676 | |
Cruzipain | Trypanosoma cruzi | 3 | |
Vasopressin V2 receptor | Homo sapiens (human) | 3.476 | |
C-C chemokine receptor type 4 | Homo sapiens (human) | 3.2689 | |
Lanosterol 14-alpha demethylase | Homo sapiens (human) | 3.6 | |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 2 |
Research
Studies (4)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (75.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
da Silva Hellwig, AH; Pagani, DM; Ribeiro, AC; Rios, IDS; Scroferneker, ML; Zanette, RA | 1 |
Reviews
1 review(s) available for deferasirox and itraconazole
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Other Studies
3 other study(ies) available for deferasirox and itraconazole
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Influence of iron on growth and on susceptibility to itraconazole in Sporothrix spp.
Topics: Antifungal Agents; Culture Media; Deferasirox; Drug Synergism; Iron; Itraconazole; Microbial Sensitivity Tests; Spores, Fungal; Sporothrix; Sporotrichosis | 2021 |