Page last updated: 2024-09-04

cyc 202 and bs-181

cyc 202 has been researched along with bs-181 in 6 studies

Compound Research Comparison

Studies
(cyc 202)
Trials
(cyc 202)
Recent Studies (post-2010)
(cyc 202)
Studies
(bs-181)
Trials
(bs-181)
Recent Studies (post-2010) (bs-181)
979739320017

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)bs-181 (IC50)
Cyclin-T1Homo sapiens (human)1.79
Cyclin-dependent kinase 1Homo sapiens (human)8.1
G1/S-specific cyclin-E1Homo sapiens (human)1.8
Cyclin-dependent kinase 2Homo sapiens (human)1.1933
Cyclin-dependent kinase 8Homo sapiens (human)4.2
Cyclin-dependent kinase 7Homo sapiens (human)0.0662
Cyclin-dependent kinase 9Homo sapiens (human)2.7233
Cyclin-HHomo sapiens (human)0.0775
CDK-activating kinase assembly factor MAT1Homo sapiens (human)0.134
Cyclin-dependent-like kinase 5 Homo sapiens (human)3.35
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)3.7

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Aboagye, EO; Ali, S; Alikian, M; Barbazanges, M; Barrett, AG; Blum, A; Brackow, J; Coombes, RC; Freemont, PS; Fuchter, MJ; Hazel, P; Heathcote, DA; Jogalekar, AS; Kanneganti, SK; Kroll, SH; Liotta, DC; Pace, RD; Patel, H; Periyasamy, M; Scheiper, B; Siwicka, A; Snyder, JP1
Baltus, CB; Bazgier, V; Berka, K; Jorda, R; Kryštof, V; Marot, C; Prié, G; Viaud-Massuard, MC1
Havlíček, L; Jorda, R; Kryštof, V; Pospíšil, T; Skrášková, Z; Strnad, M; Šturc, A; Vymětalová, L1
de Dios, A; Lallena, MJ; Sánchez-Martínez, C; Sanfeliciano, SG1
Diab, S; Wang, S; Yu, M1
Albert, T; Antrecht, C; Baumgart, K; Eickhoff, J; Kelso, TW; Klebl, B; Lemcke, S; Meisterernst, M1

Reviews

2 review(s) available for cyc 202 and bs-181

ArticleYear
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
    Bioorganic & medicinal chemistry letters, 2019, 10-15, Volume: 29, Issue:20

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Cycle Checkpoints; Cyclin-Dependent Kinases; Drug Discovery; Humans; Indoles; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Pyrimidines; Transcription Factors

2019
CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?
    Journal of medicinal chemistry, 2020, 07-23, Volume: 63, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Humans; Neoplasms; Protein Kinase Inhibitors

2020

Other Studies

4 other study(ies) available for cyc 202 and bs-181

ArticleYear
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
    Journal of medicinal chemistry, 2010, Dec-23, Volume: 53, Issue:24

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood Proteins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Female; Humans; In Vitro Techniques; Mice; Mice, Nude; Microsomes, Liver; Models, Molecular; Phosphorylation; Protein Binding; Pyrazoles; Pyrimidines; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2010
Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin E; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Indoles; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship

2016
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
    European journal of medicinal chemistry, 2016, Mar-03, Volume: 110

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; G2 Phase; Humans; Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines

2016
Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.
    Molecular and cellular biology, 2014, Oct-01, Volume: 34, Issue:19

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HEK293 Cells; HeLa Cells; Humans; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; RNA Polymerase II; RNA, Messenger; Roscovitine; Triazines

2014