Validol is a pharmaceutical preparation used as a mild sedative and antispasmodic. It is a mixture of menthol and ethyl valerate, with a characteristic minty aroma. Its mechanism of action is not fully understood, but it is believed to exert its effects by acting on the central nervous system. Validol is typically taken orally in liquid form. It is commonly used to relieve symptoms of mild anxiety, nervous tension, and headaches. However, there is limited scientific evidence to support its effectiveness. Validol is not recommended for pregnant women or breastfeeding mothers, and its use should be avoided in individuals with a history of allergies to menthol or valerian. The importance of Validol lies in its historical use as a traditional remedy for mild nervous system complaints, but it is important to note that modern medicine has more effective and scientifically supported alternatives for these conditions.'
Validol: Russian drug; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 119900 |
| SCHEMBL ID | 873739 |
| MeSH ID | M0058861 |
| Synonym |
|---|
| butanoic acid, 3-methyl-, (1r,2s,5r)-5-methyl-2-(1-methylethyl)cyclohexyl ester, rel- |
| unii-e6qe751102 |
| butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1alpha,2beta,5alpha)- |
| einecs 201-910-2 |
| menthyl isovalerate, (+/-)- |
| e6qe751102 , |
| validol |
| 89-47-4 |
| 28221-20-7 |
| [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] 3-methylbutanoate |
| (1r-(1alpha,2beta,5alpha))-2-isopropenyl-5-methylcyclohexyl isovalerate |
| unii-p5m0o284o6 |
| p5m0o284o6 , |
| menthyl isovalerate, (-)- |
| menthol isovalerate |
| einecs 248-911-4 |
| butanoic acid, 3-methyl-, (1r,2s,5r)-5-methyl-2-(1-methylethyl)cyclohexyl ester |
| butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1r-(1.alpha.,2.beta.,5.alpha.))- |
| menthyl isovalerate [mart.] |
| menthyl valerate [who-dd] |
| menthyl isovalerate [mi] |
| menthyl isovalerate racemate [mi] |
| menthyl isovalerate [fhfi] |
| fema no. 4156, (+/-)- |
| fema no. 4156, (-)- |
| p- menth-3-yl isovalerate |
| dl-menthyl isovalerate |
| l-menthyl isovalerate |
| SCHEMBL873739 |
| l-methyl isovalerate |
| (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexyl 3-methylbutanoate |
| fema 2669 |
| rel-(1r,2s,5r)-2-isopropyl-5-methylcyclohexyl 3-methylbutanoate |
| DTXSID90883268 |
| DTXSID90893827 |
| (1r,2s,5r)-2-isopropyl-5-methylcyclohexyl 3-methylbutanoate |
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have developed a genotyping system to determine the alleles of genes related to interindividual variability in acenocoumarol dosage requirements." | ( A multiplex assay to detect variations in the CYP2C9, VKORC1, CYP4F2 and APOE genes involved in acenocoumarol metabolism. Arroyo-Pardo, E; Baeza, C; Borobia, AM; Carcas, AJ; López-Parra, AM, 2013) | 0.39 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (75.85) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||