tolnidamine

Description

Tolnidamine is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. It is a derivative of indomethacin and is thought to act by inhibiting the enzyme cyclooxygenase, which is responsible for the production of prostaglandins, inflammatory mediators. Tolnidamine is used to treat pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, and gout. It is also used to treat menstrual cramps and dysmenorrhea. Tolnidamine is available in both oral and topical formulations. The synthesis of tolnidamine involves several steps, starting with the reaction of indomethacin with a suitable amine. The resulting product is then reacted with a carboxylic acid to yield tolnidamine. The exact mechanisms of action of tolnidamine are not fully understood, but it is believed to act by inhibiting the production of prostaglandins, which are involved in the inflammatory process. Tolnidamine has been studied extensively for its therapeutic potential in various inflammatory conditions. Research has shown that tolnidamine is effective in reducing pain and inflammation in patients with rheumatoid arthritis, osteoarthritis, and other inflammatory conditions. However, tolnidamine can also cause adverse effects, including gastrointestinal problems, cardiovascular problems, and liver damage. The use of tolnidamine is generally safe for short-term use, but long-term use can increase the risk of serious side effects. Tolnidamine is a relatively old drug that has been largely replaced by newer NSAIDs with better safety profiles. However, it is still used in some parts of the world for the treatment of pain and inflammation. '

tolnidamine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]