Page last updated: 2024-12-07

1-p-chlorobenzyl-1h-indazole-3-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-p-chlorobenzyl-1H-indazole-3-carboxylic acid is a synthetic organic compound with the chemical formula C15H11ClN2O2.

Here's a breakdown of its structure and importance in research:

**Structure:**

* **Indazole core:** The molecule has a core structure called indazole, which is a bicyclic aromatic ring system containing a benzene ring fused to a pyrazole ring.
* **Substitution:** At the 1 position of the indazole ring, there's a p-chlorobenzyl group, meaning a benzyl group (CH2-Ph) with a chlorine atom attached at the para (opposite) position on the benzene ring.
* **Carboxylic acid:** The molecule has a carboxylic acid (-COOH) group attached at the 3 position of the indazole ring.

**Research Importance:**

The importance of 1-p-chlorobenzyl-1H-indazole-3-carboxylic acid lies in its potential pharmacological properties and its role as a building block for other research chemicals.

Here are some potential areas of research interest:

* **Drug discovery:** The compound's structure suggests potential for biological activity. It might act as a:
* **Ligand:** It could bind to specific receptors or proteins, triggering biological effects.
* **Enzyme inhibitor:** It could block the activity of certain enzymes, potentially useful in treating various diseases.
* **Synthesis and medicinal chemistry:** The compound can serve as an intermediate in the synthesis of other more complex molecules with potential medicinal value. Researchers might modify the structure to optimize its properties and explore its therapeutic potential.
* **Material science:** The compound might exhibit unique properties like fluorescence or luminescence, making it useful in materials science applications.

**Important Note:**

It's crucial to understand that while the molecule's structure suggests potential for research, it is not necessarily a confirmed drug or a material with proven applications. Further research and development are needed to determine its true biological activity and potential applications.

**To further explore the importance of this compound:**

* **Search online databases:** Use databases like PubChem or SciFinder to find research papers or patents related to this compound.
* **Contact research groups:** Reach out to research groups working in the field of medicinal chemistry or drug discovery to inquire about their research related to this compound.

1-p-chlorobenzyl-1H-indazole-3-carboxylic acid: RN given refers to cpd with isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100493
CHEMBL ID3276570
CHEBI ID93180
SCHEMBL ID3500587
MeSH IDM0051139

Synonyms (31)

Synonym
50264-86-3
nsc309701
1h-indazole-3-carboxylic acid, 1-[(4-chlorophenyl)methyl]-
nsc-309701
mls003115871 ,
1-p-chlorobenzyl-1h-indazole-3-carboxylic acid
1h-indazole-3-carboxylic acid, 1-((4-chlorophenyl)methyl)-
nsc 309701
af 1312/ts
1-((4-chlorophenyl)methyl)-1h-indazole-3-carboxylic acid
af 1312ts
1-(4-chlorobenzyl)-1h-indazole-3-carboxylic acid
brn 0888596
OPREA1_458144
af-1312/ts
smr001831437
BRD-K67484673-001-01-5
1-[(4-chlorophenyl)methyl]indazole-3-carboxylic acid
BRD-K67484673-001-02-3
MLS003271339
AKOS012406886
CHEMBL3276570
SCHEMBL3500587
DTXSID70198266
CHEBI:93180
Q27164901
1-[(4-chlorophenyl)methyl]-3-indazolecarboxylic acid
1-(p-chlorobenzyl)indazolyl-3-carboxylic acid
E77693
AS-83009
1-[(4-chlorophenyl)methyl]-1h-indazole-3-carboxylic acid

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" AF 1312/TS (1-(4-chlorobenzyl)-1H-indazole-3-carboxylic acid) when administered from day 6 to day 15 of pregnancy produced embryolethality with an LD50 of 145 mg/kg."( The embryotoxicity of a new class of antispermatogenic agents: the 3-indazole-carboxylic acids.
Campana, A; De Martino, C; Scorza Barcellona, P; Silvestrini, B, 1982
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1150559Antispermatogenic activity in po dosed Long-Evans rat assessed as reduction of testes weight administered as single dose measured after 5 days1976Journal of medicinal chemistry, Jun, Volume: 19, Issue:6
1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (60.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.74 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]