taxinine: from Taxus cuspidata as modulators of multidrug-resistant tumor cells; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Taxus | genus | Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).[MeSH] | Taxaceae | A plant family of the order Pinales, class Pinopsida, division TRACHEOPHYTA.[MeSH] |
| Taxus cuspidata | species | [no description available] | Taxaceae | A plant family of the order Pinales, class Pinopsida, division TRACHEOPHYTA.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 10054413 |
| CHEMBL ID | 309787 |
| MeSH ID | M0448421 |
| Synonym |
|---|
| CHEMBL309787 |
| taxinine |
| 3835-52-7 |
| o-cinnamoyltaxicin-ii triacetate [mi] |
| unii-b7554596hx |
| b7554596hx , |
| taxinine, (+)- |
| taxinin |
| 2-propenoic acid, 3-phenyl-, (3s,4ar,5r,6r,11r,12r,12ar)-5,11,12-tris(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (2e)- |
| cinnamic acid, 3-ester with 1,3,4,4aalpha,5,6beta,7,11,12,12a-decahydro-3alpha,5alpha,11beta,12alpha-tetrahydroxy-9,12abeta,13,13-tetramethyl-4-methylene-6,10-methanobenzocyclodecen-8(2h)-one triacetate |
| cinnamic acid, 3-ester with 1,3,4,4a.alpha.,5,6.beta.,7,11,12,12a-decahydro-3.alpha.,5.alpha.,11.beta.,12.alpha.-tetrahydroxy-9,12a.beta.,13,13-tetramethyl-4-methylene-6,10-methanobenzocyclodecen-8(2h)-one triacetate |
| Q27274451 |
| [(1r,2r,3r,5s,8r,9r,10r)-2,9,10-triacetyloxy-8,12,15,15-tetramethyl-4-methylidene-13-oxo-5-tricyclo[9.3.1.03,8]pentadec-11-enyl] (e)-3-phenylprop-2-enoate |
| HY-N7531 |
| CS-0132691 |
| AKOS040762407 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID151341 | Amount of vincristine (VCR) accumulation in multidrug-resistant human ovarian cancer 2780AD cells at a concentration of 1 ug/mL. | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Modulation of multidrug resistance in tumor cells by taxinine derivatives. |
| AID151339 | Amount of vincristine (VCR) accumulation in multidrug-resistant human ovarian cancer 2780AD cells at a concentration of 10 ug/mL. | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Modulation of multidrug resistance in tumor cells by taxinine derivatives. |
| AID3216 | Relative activity on the cellular accumulation of vincristine in multidrug-resistant (MDR) human ovarian cancer 2780AD cells | 1999 | Bioorganic & medicinal chemistry letters, Dec-20, Volume: 9, Issue:24 | Highly increased cellular accumulation of vincristine, a useful hydrophobic antitumor-drug, in multidrug-resistant solid cancer cells induced by a simply reduced taxinine. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.92) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||