Compounds > sulfoquinovosyl dipalmitoyl glyceride
Page last updated: 2024-11-07

sulfoquinovosyl dipalmitoyl glyceride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sulfoquinovosyl dipalmitoyl glyceride: P-selectin receptor inhibitor; isolated from the alga Dictyochloris fragrans; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID159321
CHEMBL ID504516
SCHEMBL ID6925719
MeSH IDM0276384

Synonyms (13)

Synonym
sulfonoglycolipid
brn 1279617
2,3-bis((1-oxohexadecyl)oxy)propyl 6-deoxy-6-sulfo-alpha-d-glucopyranoside
sulfoquinovosyl dipalmitoyl glyceride
alpha-d-glucopyranoside, 2,3-bis((1-oxohexadecyl)oxy)propyl 6-deoxy-6-sulfo-
109430-50-4
sulfonoquinovosyl dipalmitoyl glyceride
CHEMBL504516 ,
[(2s,3s,4s,5r,6s)-6-[2,3-di(hexadecanoyloxy)propoxy]-3,4,5-trihydroxyoxan-2-yl]methanesulfonic acid
bdbm50292392
SCHEMBL6925719
DTXSID40911161
1,2-dipalmitoyl-3-o-alpha-6'''-sulfoquinovosylglycerol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
P-selectinHomo sapiens (human)IC50 (µMol)5.00005.00005.00005.0000AID403206
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
positive regulation of leukocyte migrationP-selectinHomo sapiens (human)
inflammatory responseP-selectinHomo sapiens (human)
cell adhesionP-selectinHomo sapiens (human)
leukocyte cell-cell adhesionP-selectinHomo sapiens (human)
positive regulation of platelet activationP-selectinHomo sapiens (human)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesP-selectinHomo sapiens (human)
response to lipopolysaccharideP-selectinHomo sapiens (human)
regulation of integrin activationP-selectinHomo sapiens (human)
defense response to Gram-negative bacteriumP-selectinHomo sapiens (human)
leukocyte tethering or rollingP-selectinHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionP-selectinHomo sapiens (human)
cell-cell adhesionP-selectinHomo sapiens (human)
positive regulation of leukocyte tethering or rollingP-selectinHomo sapiens (human)
response to cytokineP-selectinHomo sapiens (human)
heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesP-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
lipopolysaccharide bindingP-selectinHomo sapiens (human)
integrin bindingP-selectinHomo sapiens (human)
calcium ion bindingP-selectinHomo sapiens (human)
protein bindingP-selectinHomo sapiens (human)
heparin bindingP-selectinHomo sapiens (human)
sialic acid bindingP-selectinHomo sapiens (human)
fucose bindingP-selectinHomo sapiens (human)
glycosphingolipid bindingP-selectinHomo sapiens (human)
calcium-dependent protein bindingP-selectinHomo sapiens (human)
oligosaccharide bindingP-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
extracellular spaceP-selectinHomo sapiens (human)
plasma membraneP-selectinHomo sapiens (human)
external side of plasma membraneP-selectinHomo sapiens (human)
platelet dense granule membraneP-selectinHomo sapiens (human)
platelet alpha granule membraneP-selectinHomo sapiens (human)
extracellular spaceP-selectinHomo sapiens (human)
external side of plasma membraneP-selectinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID403206Displacement of immobilized sulfatide from P-selectin transfected in african green monkey COS cells by IgG-based competitive ELISA1997Journal of natural products, Apr, Volume: 60, Issue:4
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
AID403208Inhibition of human P-selectin-dependent adhesion of activated platelets to HL60 cells after 30 mins by flow cytometry1997Journal of natural products, Apr, Volume: 60, Issue:4
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
AID403207Inhibition of human P-selectin receptor globulin adhesion to HL60 cells1997Journal of natural products, Apr, Volume: 60, Issue:4
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.76 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,2-dimyristoylphosphatidylethanolamine
[no description available]		1.9910
glycolipids
[no description available]		3.150
ConditionIndicatedRelationship StrengthStudiesTrials