Protoverine is a natural alkaloid isolated from the plant Veratrum album. It has been studied for its potential effects on the nervous system, particularly its ability to inhibit the release of acetylcholine. Protoverine is known for its pharmacological activities, including hypotensive, antiarrhythmic, and analgesic effects. Its synthesis involves complex chemical reactions, and it has been investigated for its potential therapeutic applications. Due to its complex structure and pharmacological activities, protoverine has attracted research interest. Further research is needed to fully understand its mechanisms of action, therapeutic potential, and potential side effects.'
protoverine: RN given refers to (3beta,4alpha,6alpha,7alpha,15alpha,16beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 442982 |
| CHEBI ID | 8596 |
| SCHEMBL ID | 3127527 |
| MeSH ID | M0058709 |
| Synonym |
|---|
| (3beta,4alpha,6alpha,7alpha,15alpha,16beta)-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol |
| 6-alpha-hydroxygermine |
| cevane-3-beta,4-beta,6-alpha,7-alpha,14,15-alpha,16-beta,20-octol, 4,9-epoxy- |
| brn 0099696 |
| protoverine |
| 76-45-9 |
| C10817 , |
| 4-21-00-06841 (beilstein handbook reference) |
| cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, (3beta,4alpha,6alpha,7alpha,15alpha,16beta)- |
| q4z41i047r , |
| unii-q4z41i047r |
| CHEBI:8596 |
| SCHEMBL3127527 |
| DTXSID5023534 |
| Q27108104 |
| (1s,2s,6s,9s,10s,11r,12r,13s,14s,15s,16s,17r,18r,19s,22s,23s,25r)-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosane-10,12,13,14,16,17,22,23-octol |
| XP177672 |
| Class | Description |
|---|---|
| alkaloid | Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.66) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||