natsudaidain profile

natsudaidain: isolated from Citrus plants; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Citrus	genus	A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.[MeSH]	Rutaceae	A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID Source	ID
PubMed CID	3084605
CHEMBL ID	225702
CHEBI ID	191571
SCHEMBL ID	890712
MeSH ID	M0245152

Synonyms (21)

Synonym
natsudaidain
4h-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3-hydroxy-5,6,7,8-tetramethoxy-
28441ild21 ,
35154-55-3
unii-28441ild21
3-hydroxynobiletin
CHEMBL225702
3-hydroxy-3',4',5,6,7,8-hexamethoxyflavone
LMPK12113344
2-(3,4-dimethoxyphenyl)-3-hydroxy-5,6,7,8-tetramethoxychromen-4-one
SCHEMBL890712
DTXSID00188655 ,
3-hydroxy-5,6,7,8,3',4'-hexamethoxyflavone
dtxcid60111146
3',4',5,6,7,8-hexamethoxyflavonol
2-(3,4-dimethoxyphenyl)-3-hydroxy-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-one
Q3337057
CHEBI:191571
FS-7396
2-(3,4-dimethoxyphenyl)-3-hydroxy-5,6,7,8-tetramethoxy-4h-chromen-4-one
AKOS040735020

Class	Description
hydroxyflavan	A member of the class of flavans in which one or more ring hydrogens are replaced by hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID1092127	Antifungal activity against Aspergillus niger CICC 2273 assessed as inhibition of mycelial growth by microbroth dilution method	2012	Journal of agricultural and food chemistry, May-02, Volume: 60, Issue:17	Structure-activity relationship of citrus polymethoxylated flavones and their inhibitory effects on Aspergillus niger.
AID288086	Antiproliferative activity against HL60 after 24 hrs	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID288087	Apoptotic activity in HL60 cells after 24 hrs	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID288088	Cytotoxicity against human PMN cells at 100 uM	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (33.33)	18.2507
2000's	2 (33.33)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.74 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.74)

All Compounds (24.57)

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	1.99	1	flavones	metabolite; nematicide
tangeretin tangeretin: structure given in first source; from citrus plants; inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. tangeretin : A pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8.. pentamethoxyflavone : A methoxyflavone that is flavone substituted by a five methoxy groups.	2.03	1	pentamethoxyflavone	antineoplastic agent; plant metabolite
nobiletin nobiletin : A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.	2.95	4	methoxyflavone	antineoplastic agent; plant metabolite
4',5,6,7-tetramethoxyflavone 4',5,6,7-tetramethoxyflavone: structure given in first source; from plant Eupatorium odoratum. 4',5,6,7-tetramethoxyflavone : A tetramethoxyflavone that is the tetra-O-methyl derivative of scutellarein.	2.07	1	tetramethoxyflavone	antimutagen; plant metabolite
gardenin b gardenin B: has antineoplastic activity; structure in first source. gardenin B : A tetramethoxyflavone that is tangeretin in which the methoxy group at position 5 has been replaced by a hydroxy group.	2.03	1	monohydroxyflavone; tetramethoxyflavone	plant metabolite
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: has antineoplastic activity; structure in first source	2.03	1	ether; flavonoids
sinensetin sinensetin: isolated from citrus fruit; exhibit antiadhesive action on platelets. sinensetin : A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.	2.03	1	pentamethoxyflavone	plant metabolite
3,3',4',5,6,7,8-heptamethoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone: has anti-inflammatory activity; isolated from citrus fruit; exhibit antiadhesive action on platelets	2.69	3	ether; flavonoids
5-hydroxy-3',4',6,7-tetramethoxyflavone 5-hydroxy-3',4',6,7-tetramethoxyflavone: isolated from Artemisia argyi	2.03	1
3'-demethylnobiletin 3'-demethylnobiletin: structure in first source	2.03	1	ether; flavonoids
gardenin a gardenin A: promotes neurite outgrowth; structure in first source	2.03	1
5-demethylnobiletin 5-demethylnobiletin: antineoplastic from Citrus plants; structure in first source	2.46	2	ether; flavonoids
3',4'-didemethylnobiletin 3',4'-didemethylnobiletin: a urinary metabolite derived from nobiletin; has anti-inflammatory and antitumor activities; structure in first source	2.03	1
artemetin [no description available]	2.03	1	ether; flavonoids
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	2.05	1	benzoxazole
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone: structure in first source	2.03	1	ether; flavonoids

natsudaidain

Description

Cross-References

Synonyms (21)

Drug Classes (1)

Bioassays (4)

Research

Studies (6)

Market Indicators

Research Demand Index: 17.74

Study Types

natsudaidain

Description

Related Flora

Cross-References

Synonyms (21)

Drug Classes (1)

Bioassays (4)

Research

Studies (6)

Market Indicators

Research Demand Index: 17.74

Study Types

Related Drugs (16)

Related Conditions (0)