Page last updated: 2024-12-07

lemax

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID78458
CHEMBL ID86532
SCHEMBL ID45299
MeSH IDM0199237

Synonyms (54)

Synonym
n-phenyl-phthalamic acid
CHEMBL86532 ,
phthalanillic acid
unii-bl6zpy93nn
bl6zpy93nn ,
4-12-00-00483 (beilstein handbook reference)
benzoic acid, 2-((phenylamino)carbonyl)-
phthalanilic acid
benzoic acid, 2-[(phenylamino)carbonyl]-
nsc26414
nsc-26414
4727-29-1
SDCCGMLS-0007558.P002
n-phenylphthalamic acid
phthalomonoanilide
nevirol
brn 2215395
phthalic monoanilide
ai3-31209
o-(phenylcarbamoyl)benzoic acid
lemax
2-((phenylamino)carbonyl)benzoic acid
nsc 26414
MLS000058750
smr000069015
2-(anilinocarbonyl)benzoic acid
OPREA1_544727
MAYBRIDGE1_006710
bdbm50136853
HMS560I22
F0777-0791
2-(phenylcarbamoyl)benzoic acid
AKOS002288922
HMS2392M15
FT-0635413
AB00391834-10
SCHEMBL45299
phthalanilsaure
DTXSID00197080
Z90311206
BBL104239
STL558305
SY039683
mfcd00029939
phthalic acid monoanilide
n-phenylphthalamidic acid
2-carboxybenzanilide
AMY12560
MS-20516
nsc26414;nevirol
AC6191
A901428
EN300-235671
CS-0067669
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency35.48130.011212.4002100.0000AID1030
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.11871.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aldo-keto reductase family 1 member B1Sus scrofa (pig)IC50 (µMol)227.00000.01500.61352.5000AID34780
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID127751Plasma cholesterol level was evaluated in Swiss white mice treated with 20 mg/kg/day of ip administration for 14 days2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
AID140341Plasma triglyceride level was evaluated in Swiss white mice treated with 20 mg/kg/day of ip administration for 14 days2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
AID34780Inhibition of pig kidney aldose reductase (ALR2)2003Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
Rational design of an indolebutanoic acid derivative as a novel aldose reductase inhibitor based on docking and 3D QSAR studies of phenethylamine derivatives.
AID129085Animal body weight was evaluated in Swiss white mice before treatment with the compound2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
AID140340Plasma triglyceride level was evaluated in Swiss white mice before treatment with the compound2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
AID127750Plasma cholesterol level was evaluated in Swiss white mice before treatment with the compound2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
AID129086Animal body weight was evaluated in Swiss white mice treated with 20 mg/kg/day of ip administration for 14 days2001Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
Microwave assisted synthesis of N-arylphthalamic acids with hyperlipidemic activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 63.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index63.03 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index200.54 (26.88)
Search Engine Supply Index3.97 (0.95)

This Compound (63.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]