Page last updated: 2024-12-07
l 30
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
L 30: a sodium channel blocker; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 88832 |
CHEMBL ID | 10321 |
SCHEMBL ID | 18485526 |
MeSH ID | M0243416 |
Synonyms (11)
Synonym |
---|
l 30 |
CHEMBL10321 |
21236-52-2 |
3-(diethylamino)-n-(2,6-dimethylphenyl)propanamide |
3-(diethylamino)-2',6'-propionoxylidide |
2',6'-propionoxylidide, 3-(diethylamino)- |
AKOS028302367 |
SCHEMBL18485526 |
propanamide, 3-(diethylamino)-n-(2,6-dimethylphe |
DTXSID90877900 |
STARBLD0004663 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (29)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID317685 | Anesthetic activity in rat at 4.0 uMol/site assessed as duration of full recovery of sensory block | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. |
AID114641 | Compound was evaluated for ataxia in mice | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
AID1130840 | Antiarrhythmic activity in left anterior descending coronary artery ligated myocardial infarction model of dog assessed as mean arterial blood pressure at 0.5 mg/kg/min, iv | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID317683 | Anesthetic activity in rat at 1.0 uMol/site assessed as duration of full recovery of sensory block | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. |
AID25320 | Dissociation constant (pKa) | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
AID1130830 | Toxicity in mouse assessed as ataxia at 100 mg/kg, sc measured up to 20 mins | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130836 | Antiarrhythmic activity in sc dosed mouse assessed as protection against chloroform-induced fibrillation | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID114025 | Effective dose of compound that evoked CNS toxicity in mice in the form of ataxia | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID317684 | Anesthetic activity in rat at 2.0 uMol/site assessed as duration of full recovery of sensory block | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. |
AID1130833 | Toxicity in mouse assessed as mortality at 100 mg/kg, sc measured up to 20 mins | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID235211 | Therapeutic index is the ratio of ED50 (ataxia) to ED50 (protection) in mice | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
AID1130848 | Toxicity in iv dosed left anterior descending coronary artery ligated myocardial infarction model of dog at 0.25 mmol/kg, iv | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130844 | Toxicity in iv dosed left anterior descending coronary artery ligated myocardial infarction model of dog assessed as dose required to cause convulsion | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130839 | Antiarrhythmic activity in left anterior descending coronary artery ligated myocardial infarction model of dog assessed as clearing value of ventricular rate at 0.5 mg/kg/min, iv | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID23494 | Partition coefficient (logP) | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
AID1130832 | Toxicity in mouse assessed as loss of righting reflex at 100 mg/kg, sc measured up to 20 mins | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130841 | Antiarrhythmic activity in iv dosed left anterior descending coronary artery ligated myocardial infarction model of dog assessed as dose required for reduction of ectopic beats to <= 5% | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID23097 | Compound was evaluated for -Log [fraction ionized x ED50 (protection)] | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
AID174603 | Anesthetic activity of compound (1.25%) was evaluated by duration of sciatic nerve block; Required days for complete recovery of normal motor function. | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID114027 | Effective dose of compound that protects mice against chloroform induced tachycardia | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID317682 | Anesthetic activity in rat at 0.5 uMol/site assessed as duration of full recovery of sensory block | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. |
AID1130846 | Cardiovascular toxicity in iv dosed left anterior descending coronary artery ligated myocardial infarction model of dog | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID174596 | Anesthetic activity of compound (0.25%) was evaluated by duration of sciatic nerve block | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID174599 | Anesthetic activity of compound (1.0%) was evaluated by duration of sciatic nerve block | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID1130838 | Antiarrhythmic activity in left anterior descending coronary artery ligated myocardial infarction model of dog assessed as clearing value of ventricular ectopic beats at 0.5 mg/kg/min, iv | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130847 | Toxicity in iv dosed left anterior descending coronary artery ligated myocardial infarction model of dog at 0.20 mmol/kg, iv | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID1130837 | Ratio of lidocaine ED50 to compound ED50 for antiarrhythmic activity sc dosed mouse assessed as protection against chloroform-induced fibrillation | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10 | New antiarrhythmic agents. 3. Primary beta-amino anilides. |
AID174598 | Anesthetic activity of compound (0.5%) was evaluated by duration of sciatic nerve block | 1981 | Journal of medicinal chemistry, Sep, Volume: 24, Issue:9 | New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides. |
AID114662 | Compound was evaluated for protection against tachycardia in mice | 1981 | Journal of medicinal chemistry, Jul, Volume: 24, Issue:7 | New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 4 (66.67) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 62.52
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (62.52) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |