Karwinskia toxin T-544: structure given in first source; isolated from Karwinskia humboldtiana (do not confuse with Rhamnus) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Karwinskia | genus | A plant genus of the family RHAMNACEAE that contains tullidinol (toxin T-544) and peroxisomicine (toxin T-514). It is sometimes called buckthorn but should not be confused with other plants called that.[MeSH] | Rhamnaceae | The buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.[MeSH] |
| Karwinskia humboldtiana | species | [no description available] | Rhamnaceae | The buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 99832 |
| MeSH ID | M0202574 |
| Synonym |
|---|
| 1(2h)-anthracenone, 7-(3,4-dihydro-10-hydroxy-7,9-dimethoxy-1,3-dimethyl-1h-naphtho(2,3-c)pyran-5-yl)-3,4-dihydro-3,8,9-trihydroxy-3-methyl- |
| T544 , |
| tullidinol |
| toxin t 544 |
| 1(2h)-anthracenone, 3,4-dihydro-7-(3,4-dihydro-10-hydroxy-7,9-dimethoxy-1,3-dimethyl-1h-naphtho(2,3-c)pyran-5-yl)-3,8,9-trihydroxy-3-methyl- |
| t 544 |
| t-544 toxin |
| karwinskia toxin t-544 |
| 56678-09-2 |
| nsc-235814 |
| nsc235814 |
| 3,8,9-trihydroxy-7-(10-hydroxy-7,9-dimethoxy-1,3-dimethylbenzo[g]isochroman-5-yl)-3-methyl-2,3,4-trihydroanthracen-1-one |
| 3,8,9-trihydroxy-7-(10-hydroxy-7,9-dimethoxy-1,3-dimethyl-3,4-dihydro-1h-benzo[g]isochromen-5-yl)-3-methyl-2,4-dihydroanthracen-1-one |
| t-544 |
| nsc 235814 |
| toxin 544, karwinskia |
| 3,8,9-trihydroxy-7-(10-hydroxy-7,9-dimethoxy-1,3-dimethyl-3,4-dihydro-1h-naphtho[2,3-c]pyran-5-yl)-3-methyl-3,4-dihydroanthracen-1(2h)-one |
| DTXSID90972126 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Both toxins were shown to be highly hepatotoxic; T-514 was more toxic than T-544." | ( Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Acosta, D; Garza-Ocañas, L; Hsieh, GC; Piñeyro-López, A; Torres-Alanís, O, 1992) | 0.28 |
| " Both toxins were shown to be highly hepatotoxic; T-514 was more toxic than T-544." | ( Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Acosta, D; Garza-Ocañas, L; Hsieh, GC; Piñeyro-López, A; Torres-Alanís, O, 1992) | 0.28 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.37) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||