Compounds > karwinskia toxin t-514
Page last updated: 2024-11-12

karwinskia toxin t-514

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Karwinskia toxin T-514: structure given in first source; isolated from Karwinskia humboldtiana [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
KarwinskiagenusA plant genus of the family RHAMNACEAE that contains tullidinol (toxin T-544) and peroxisomicine (toxin T-514). It is sometimes called buckthorn but should not be confused with other plants called that.[MeSH]RhamnaceaeThe buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.[MeSH]
Karwinskia humboldtianaspecies[no description available]RhamnaceaeThe buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.[MeSH]

Cross-References

ID SourceID
PubMed CID11386735
CHEMBL ID3355662
MeSH IDM0202577

Synonyms (17)

Synonym
karwinskia toxin t-514
karwinskia humboldtiana toxin, t-514
brn 2687083
(2,9'-bianthracene)-4',8(1'h,5h)-dione, 2',3',6,7-tetrahydro-2',6-dimethyl-1,2',5',6,9,10'-hexahydroxy-
2',6-dimethyl-1,2',5',6,9,10'-hexahydroxy-2',3',6,7-tetrahydro-(2,9'-bianthracene)-4',8(1'h,5h)-dione
t-514
toxin t 514
t 514
peroxisomicine a1
110270-61-6
unii-q308rht4pv
q308rht4pv ,
toxin t-514
(2,9'-bianthracene)-4',8(1'h,5h)-dione, 2',3',6,7-tetrahydro-1,2',5',6,9,10'-hexahydroxy-2',6-dimethyl-, (2s,2's,6s)-
CHEMBL3355662
Q27286939
(3s)-3,8,9-trihydroxy-3-methyl-7-[(2s)-2,5,10-trihydroxy-2-methyl-4-oxo-1,3-dihydroanthracen-9-yl]-2,4-dihydroanthracen-1-one

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Both toxins were shown to be highly hepatotoxic; T-514 was more toxic than T-544."( Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures.
Acosta, D; Garza-Ocañas, L; Hsieh, GC; Piñeyro-López, A; Torres-Alanís, O, 1992)		0.28
" Both toxins were shown to be highly hepatotoxic; T-514 was more toxic than T-544."( Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures.
Acosta, D; Garza-Ocañas, L; Hsieh, GC; Piñeyro-López, A; Torres-Alanís, O, 1992)		0.28
" T-514, in particular, has been shown to be toxic to liver and lung as well as to tumoral cell lines, preferentially to those from liver tumors."( Genotoxic effects of Karwinskia humboldtiana toxin T-514 in peripheral blood lymphocytes.
Gonsebatt, ME; Montero, R; Ostrosky-Wegman, P; Piñeyro, A; Rojas, E; Sordo, M; Velazco, MR, 1996)		0.29

Pharmacokinetics

ExcerptReferenceRelevance
" An animal model (New Zeland white rabbit) was selected for pharmacokinetic studies that would allow the performance of surgical techniques to catheterize central vessels in order to obtain blood samples at short time intervals."( [Pharmacokinetic design for the preclinical phase. Application to the study of an anthracenone].
Adame-Reyna, M; Belmontes-Hernández, R; Guerrero-Olazarán, M; Viader-Salvadó, JM, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1171235Cytotoxicity against human U373 cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
AID1171231Cytotoxicity against human A549 cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
AID1171234Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
AID1171233Cytotoxicity against human ZR-7530 cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
AID1171236Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
AID1171232Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's12 (52.17)18.2507
2000's6 (26.09)29.6817
2010's2 (8.70)24.3611
2020's3 (13.04)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.20 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		210alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
mitoxantrone
Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.		210dihydroxyanthraquinoneanalgesic;
antineoplastic agent
neutral red
Neutral Red: A vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.. neutral red : A hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.		1.9810hydrochlorideacid-base indicator;
dye;
two-colour indicator
etoposide
[no description available]		2.110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
karwinskia toxin t-544
Karwinskia toxin T-544: structure given in first source; isolated from Karwinskia humboldtiana (do not confuse with Rhamnus)		2.940
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.1710
glucagon
Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.		2.610peptide hormone
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor		210
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma, Basal Cell
[description not available]		02.610
Cancer of Pancreas
[description not available]		03.5240
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.610
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		03.5240
Adverse Drug Event
[description not available]		03.1710
Benign Neoplasms
[description not available]		03.1710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.1710
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.		03.1710
Cancer of Colon
[description not available]		01.9810
Cancer of Liver
[description not available]		01.9810
Cancer of Lung
[description not available]		01.9810
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9810
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9810
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9810
Abnormalities, Autosome
[description not available]		01.9910
Acute Liver Injury, Drug-Induced
[description not available]		01.9910
Liver Dysfunction
[description not available]		01.9910
Edema, Pulmonary
[description not available]		01.9910
Liver Diseases
Pathological processes of the LIVER.		01.9910
Pulmonary Edema
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.		01.9910
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		01.9910
Hepatocellular Carcinoma
[description not available]		0210
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		0210