Compounds > isomalyngamide a
Page last updated: 2024-11-12

isomalyngamide a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isomalyngamide A: from the Hawaiian cyanobacterium Lyngbya majuscula; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10626553
CHEMBL ID2147270
MeSH IDM0379932

Synonyms (4)

Synonym
isomalyngamide a
CHEMBL2147270
(e,7s)-n-[(e,2z)-2-(chloromethylidene)-4-methoxy-6-(3-methoxy-5-oxo-2h-pyrrol-1-yl)-6-oxohex-4-enyl]-7-methoxy-n-methyltetradec-4-enamide
DTXSID901046525
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID687959Antimetastatic activity in human MDA-MB-231 cells assessed as inhibition of serum-induced cellular migration at 150 nM after 24 hrs by wound healing assay2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
AID687960Antimetastatic activity in human MDA-MB-231 cells assessed as inhibition of cell migration-associated wound closure at 150 nM after 24 hrs of scratching by wound-healing assay2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
AID687958Antimetastatic activity in human MDA-MB-231 cells assessed as inhibition of serum-induced cellular migration after 16 hrs by Boyden chamber assay2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
AID687954Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
AID687956Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
AID687968Inhibition of rat liver alpha 2,3-sialyltransferase2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.		2.2510alkane-alpha,omega-diaminehuman metabolite;
mouse metabolite;
reagent
ethylenediamine
ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.		2.2510alkane-alpha,omega-diamineGABA agonist
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.3460pyrrole;
secondary amine
glycosides
[no description available]		2.2510
ribose
ribopyranose : The pyranose form of ribose.		2.2510D-ribose;
ribopyranose
ConditionIndicatedRelationship StrengthStudiesTrials
Metastase
[description not available]		02.0610
Benign Neoplasms
[description not available]		02.0610
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0610
Breast Cancer
[description not available]		07.5420
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.5420
Leukemia L 1210
[description not available]		02.1710
Adenocarcinoma, Basal Cell
[description not available]		02.0810
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0810