isomalyngamide-a and Neoplasms

isomalyngamide-a has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for isomalyngamide-a and Neoplasms

Article	Year
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway. Topics: Amides; Blotting, Western; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Magnetic Resonance Spectroscopy; Neoplasm Metastasis; Neoplasms; Proto-Oncogene Proteins c-akt; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared	2011

Article

Year

Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.

European journal of medicinal chemistry, 2011, Volume: 46, Issue:9

Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway.

Topics: Amides; Blotting, Western; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Magnetic Resonance Spectroscopy; Neoplasm Metastasis; Neoplasms; Proto-Oncogene Proteins c-akt; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared

2011