ignosterol profile

Ignosterol is a sterol found in the fungal pathogen Candida albicans. It is a key component of the fungal cell membrane and is essential for fungal viability. Ignosterol is synthesized via the ergosterol biosynthesis pathway, which is a target for antifungal drugs. The inhibition of ergosterol biosynthesis is a common mechanism of action for antifungals, such as fluconazole and itraconazole. Ignosterol is also involved in fungal virulence and is a potential target for the development of new antifungal drugs. The study of ignosterol helps to understand the mechanisms of fungal growth and virulence, and to develop new antifungal therapies. '

ignosterol: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	90278
MeSH ID	M0064444

Synonyms (13)

Synonym
23839-47-6
ignosterol
5alpha-ergosta-8,14-dien-3beta-ol
(3s,5s,10s,13r,17r)-17-[(2r,5s)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,11,12,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol
shk5f5q59m ,
unii-shk5f5q59m
(24s)-5.alpha.-ergosta-8,14-dien-3.beta.-ol
.delta.8(9),14-ergostadienol
5.alpha.-ergosta-8,14-dien-3.beta.-ol
ergosta-8,14-dien-3-ol, (3.beta.,5.alpha.)-
5.alpha.-ergost-8,14-dien-3.beta.-ol
Q27289212
DTXSID90946645

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	4 (80.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.67 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.88 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.67)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fenpropidine fenpropidine: RN given refers to parent cpd. 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine : A member of the class of piperidines that is N-isobutylpiperidine in which a hydrogen of one of the methyl groups is replaced by a p-tert-butylphenyl group.. fenpropidin : A racemate comprising equimolar amounts of (R)- and (S)-fenpropidin. A systemic fungicide, it is used for the control of foliar diseases in cereals and sugar beet.	1.98	1	piperidines; tertiary amine
fenpropimorph [no description available]	1.99	1	alkylbenzene
ergosterol [no description available]	3.08	5	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
a25822b A25822B: RN given refers to (3beta,5alpha)-isomer; structure	1.96	1
piperidines Piperidines: A family of hexahydropyridines.	1.98	1

ignosterol

Description