Hexedine is a synthetic antiseptic agent that is commonly used in oral care products. It is a cationic bis-biguanide compound, which means it contains two biguanide groups. Hexedine is effective against a broad spectrum of bacteria, including gram-positive and gram-negative bacteria, as well as some fungi and viruses. It is believed to work by disrupting the bacterial cell membrane. Hexedine is often used in mouthwashes, gargles, and toothpastes to prevent and treat gingivitis, plaque buildup, and bad breath. Hexedine is also being investigated for its potential use in treating other infections, such as skin infections and wound infections.'
| ID Source | ID |
|---|---|
| PubMed CID | 22291 |
| CHEMBL ID | 2104884 |
| SCHEMBL ID | 151813 |
| MeSH ID | M0173704 |
| Synonym |
|---|
| nsc-356715 |
| w 4701 |
| hexedine |
| nsc356715 |
| 1h-imidazo[1, 2,6-bis(2-ethylhexyl)hexahydro-7a-methyl- |
| 2,5-c]imidazole |
| 5980-31-4 |
| sterisol |
| sterisol (tn) |
| hexedine (usan/inn) |
| D04437 |
| 2,6-bis(2-ethylhexyl)-7a-methyl-1,3,5,7-tetrahydroimidazo[1,5-c]imidazole |
| CHEMBL2104884 |
| w-4701 , |
| hexedina [inn-spanish] |
| esedina [dcit] |
| unii-lre2528y9e |
| 1h-imidazo(1,5-c)imidazole, 2,6-bis(2-ethylhexyl)hexahydro-7a-methyl- |
| hexedinum [inn-latin] |
| hexedinum |
| 2,6-bis(2-ethylhexyl)-hexahydro-7a-methyl-1h-imidazo(1,5-c)imidazole |
| hexedina |
| nsc 356715 |
| hexedine [usan:inn] |
| esedina |
| lre2528y9e , |
| SCHEMBL151813 |
| hexedine [mi] |
| 2,6-bis(2-ethylhexyl)-hexahydro-7a-methyl-1h-imidazo[1,5-c]imidazole |
| hexedine [inn] |
| hexetidine impurity c [ep impurity] |
| hexedine [usan] |
| hexetidine imp. c (ep); 2,6-bis(2-ethylhexyl)-7a-methylhexahydro-1h-imidazo[1,5-c]imidazole; hexedine; hexetidine impurity c |
| 2,6-bis(2-ethylhexyl)-7a-methylhexahydro-1h-imidazo[1,5-c]imidazole (hexedine) |
| Q27283149 |
| 2,6-bis(2-ethylhexyl)-7a-methylhexahydro-1h-imidazo[1,5-c]imidazole |
| DTXSID70863669 |
| AKOS040752012 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.77) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (20.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||