Compounds > hedychenone

Page last updated: 2024-11-12

hedychenone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

hedychenone: from Hedychium yunnanense [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Hedychium	genus	[no description available]	Zingiberaceae	A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]
Hedychium yunnanense	species	[no description available]	Zingiberaceae	A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]

Cross-References

ID Source	ID
PubMed CID	12067184
CHEMBL ID	450467
MeSH ID	M0507091

Synonyms (13)

Synonym
hedychenone
CHEMBL450467
56324-54-0
(4s,4ar,8as)-4-[(e)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-5,6,7,8a-tetrahydro-4h-naphthalen-1-one
4-[2-(3-furanyl)ethenyl]-4a,5,6,7,8,8a-hexahydro-3,4a,8,8-tetramethyl- 1(4h)-naphthalenone (chem. abs. name)
1(4h)-naphthalenone, 4-[2-(3-furanyl)ethenyl]-4a,5,6,7,8,8a-hexahydro-3,4a,8,8-tetramethyl-, [4s-[4(e),4a,8a]]-; (4s,4ar,8as)-4-[(1e)-2-(3-furanyl)ethenyl]-4a,5,6,7,8,8a-hexahydro-3,4a,8,8-tetramethyl-1(4h)-naphthalenone
rel-(4r,4as,8ar)-4-[(1e)-2-(3-furanyl)ethenyl]-4a,5,6,7,8,8a-hexahydro-3,4a,8,8-tetramethyl-1(4h)-naphthalenone
DTXSID401107930
919103-33-6
AKOS040761821
FS-10016
CS-0024576
HY-N4062

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID538233	Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium.
AID475960	Cytotoxicity against human MCF7 cells after 24 hrs	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.
AID475961	Cytotoxicity against human HL60 cells after 24 hrs	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.
AID538234	Growth inhibition of human MCF7 cells by Sulforhodamine B assay	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium.
AID538235	Growth inhibition of human HeLa cells by Sulforhodamine B assay	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium.
AID538232	Growth inhibition of human A549 cells by Sulforhodamine B assay	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium.
AID475963	Cytotoxicity against human A375 cells after 24 hrs	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.
AID475964	Cytotoxicity against human A549 cells after 24 hrs	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.
AID352466	Inhibition of rat intestinal alpha-glucosidase activity at 100 ugmL	2009	Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9	New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
AID475962	Cytotoxicity against CHO cells after 24 hrs	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
nocodazole [no description available]	2.05	1	0	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
alkenes [no description available]	2.03	1	0
acarbose [no description available]	2.05	1	0	amino cyclitol; glycoside
ethyl ferulate ethyl ferulate: structure in first source	2.05	1	0
coniferaldehyde coniferaldehyde: from aqueous extract of Senra incana. coniferyl aldehyde : A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.	2.05	1	0	cinnamaldehydes; guaiacols; phenylpropanoid	antifungal agent; plant metabolite
coronarin d coronarin D: from Hedychium coronarium; inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis; structure in first source	2.05	1	0