coronarin D: from Hedychium coronarium; inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Hedychium | genus | [no description available] | Zingiberaceae | A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 52947373 |
| CHEMBL ID | 1288153 |
| MeSH ID | M0526601 |
| Synonym |
|---|
| coronarin d |
| CHEMBL1288153 |
| 119188-37-3 |
| 2(3h)-furanone,3-[2-[(1s,4as,8as)-decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-5-hydroxy-,(3e)- |
| A892637 |
Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Coronarin D is a diterpene, which is isolated from the Hedychium coronarium." | ( Benzo(A)Pyrene-Induced Lung Cancer: Chemo Protective Effect of Coronarin D in Swiss Albino Mice. Li, J; Ma, H; Seshadri, VD; Wang, X; Wu, Y, 2023) | 1.87 |
| "Coronarin D is a diterpene obtained from the rhizome extract of" | ( Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line. B Longato, G; D Torre, A; de Carvalho, JE; M Franco, YE; M Imamura, P; M Reis, R; N Rosa, M; O Silva, VA; P Paiva, P; T G Ruiz, AL; Y Okubo, M, 2019) | 2.68 |
| "Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. " | ( Antimicrobial activity of coronarin D and its synergistic potential with antibiotics. Chimnoi, N; Khunnawutmanotham, N; Reuk-ngam, N; Techasakul, S, 2014) | 2.15 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Coronarin D (CD) has been confirmed to have anti-inflammatory, anti-bacterial effects, and anti-apoptotic effects in human hepatocellular carcinoma and nasopharyngeal carcinoma." | ( Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway. Chen, G; Chen, MK; Chou, MC; Chuang, YC; Hsi, YT; Hsieh, MJ; Lin, CC; Lin, JT; Liu, YT; Lo, YS, 2019) | 2.68 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "On treatment with Coronarin D, the level of neutrophils, lymphocytes, leucocytes, and absolute neutrophils was elevated in the B(a)P-administered mice." | ( Benzo(A)Pyrene-Induced Lung Cancer: Chemo Protective Effect of Coronarin D in Swiss Albino Mice. Li, J; Ma, H; Seshadri, VD; Wang, X; Wu, Y, 2023) | 1.47 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID538232 | Growth inhibition of human A549 cells by Sulforhodamine B assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. |
| AID632580 | Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-12p40 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells. |
| AID632578 | Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated TNF-alpha production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells. |
| AID538233 | Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. |
| AID538235 | Growth inhibition of human HeLa cells by Sulforhodamine B assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. |
| AID632579 | Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-6 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells. |
| AID538234 | Growth inhibition of human MCF7 cells by Sulforhodamine B assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 6 (37.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.06) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.25%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (93.75%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||