deoxy-5-methylcytidylic acid

Description

Deoxy-5-methylcytidylic acid, also known as 5-methyldeoxycytidine monophosphate or dCMP, is a nucleoside monophosphate that is a component of DNA. It is formed by the methylation of deoxycytidylic acid (dCMP) at the 5-position of the cytosine base. dCMP is synthesized in the body from deoxyribose-1-phosphate, ATP, and CTP through a series of enzymatic reactions. 5-methyldeoxycytidine is incorporated into DNA during replication and is a common modification found in mammalian genomes. dCMP is involved in the regulation of gene expression through its role in methylation. The methylation of cytosine to 5-methylcytosine is a key epigenetic modification that can alter gene expression without changing the underlying DNA sequence. 5-methylcytosine is a key component of CpG islands, which are regions of DNA that are particularly enriched in CpG dinucleotides. CpG islands are often located near the promoters of genes and are involved in the regulation of gene expression. The study of dCMP is important for understanding the mechanisms of DNA replication, repair, and gene expression. It is also important for understanding the role of epigenetic modifications in disease. Deoxy-5-methylcytidylic acid is often investigated in the context of cancer research. It is being studied for its potential role in cancer development and progression. Research is also underway to develop drugs that target dCMP methylation as a potential cancer therapy.'

2'-deoxy-5-methyl-5'-cytidylic acid : A pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having 5-methylcytidine as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]