Page last updated: 2024-11-12

dehydroaltenusin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dehydroaltenusin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14824648
MeSH IDM0251819

Synonyms (11)

Synonym
dehydroaltenusin
6h-dibenzo(b,d)pyran-2,6(4ah)-dione, 3,7-dihydroxy-9-methoxy-4a-methyl-, (4as)-
U0VV30G3Y4 ,
altenusin, dehydro-
3,7-dihydroxy-9-methoxy-4a-methyl-4ah-benzo(c)chromene-2,6-dione
unii-u0vv30g3y4
31186-13-7
(4as)-3,7-dihydroxy-9-methoxy-4a-methylbenzo[c]chromene-2,6-dione
HY-100513A
CS-0019645
AKOS040741620

Research Excerpts

Overview

Dhydroaltenusin is a selective inhibitor of mammalian DNA polymerase alpha (pol alpha) from a fungus (Alternaria tennuis) It was found to be an inhibitor of pol alpha in vitro.

ExcerptReferenceRelevance
"Dehydroaltenusin is a selective inhibitor of mammalian DNA polymerase alpha (pol alpha) from a fungus (Alternaria tennuis). "( Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.
Fukudome, K; Imamoto, N; Kuramochi, K; Kuriyama, I; Mizuno, T; Mizushina, Y; Sakaguchi, K; Sugawara, F; Tsubaki, K; Usui, T; Yoshida, H, 2008
)
2.19
"Dehydroaltenusin was found to be an inhibitor of mammalian DNA polymerase alpha (pol alpha) in vitro. "( Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor.
Asahara, H; Hanaoka, F; Kamisuki, S; Linn, S; Matsukage, A; Mizuno, T; Mizushina, Y; Sakaguchi, K; Saneyoshi, M; Sugawara, F; Takemura, M; Yamaguchi, T; Yoshida, S, 2000
)
3.19
"Dehydroaltenusin was found to be an inhibitor of mammalian DNA polymerase alpha (pol. "( Actions of derivatives of dehydroaltenusin, a new mammalian DNA polymerase alpha-specific inhibitor.
Kamisuki, S; Mizushina, Y; Murakami, C; Ohta, K; Sakaguchi, K; Sugawara, F; Yoshida, H, 2002
)
2.06

Treatment

ExcerptReferenceRelevance
"Dehydroaltenusin treatment of OK cells engendered fluctuations in the numbers of chromosomes in the OK cells as well as inhibition of cell growth and DNA replication."( Growth inhibition and chromosomal instability of cultured marsupial (opossum) cells after treatment with DNA polymerase α inhibitor.
Kazama, T; Mizushina, Y; Oshima, T; Sakuma, K; Takemura, M, 2011
)
1.09
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's8 (66.67)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.29 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.85 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]