Page last updated: 2024-10-15

darutoside

Description

darutoside: from Siegesbeckia glabrescens Mak; RN given refers to (2R-(2alpha,4aalpha,4bbeta,7alpha(R*),10abeta)) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	146159280
MeSH ID	M0173893

Synonyms (2)

Synonym
darutoside
59219-65-7

Pharmacokinetics

Excerpt	Reference
" The present method was successfully applied to the pharmacokinetic study of kirenol in male Sprague-Dawley rats after oral administration at a dose of 50 mg/kg."	( A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study. Fu, HZ; Qian, RQ; Song, XL; Wang, ZM; Zhang, QY, 2011)

Dosage Studied

Excerpt	Reference
" Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg."	( [Studies on antifertility constituents of Siegesbeckia glabrescens Mak]. Chen, M; Dong, XY; Huang, DX; Jin, W; Li, HT; Shen, SM, 1989)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	3 (50.00)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hesperidin Hesperidin: A flavanone glycoside found in CITRUS fruit peels.. hesperidin : A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	7.31	1	3'-hydroxyflavanones; 4'-methoxyflavanones; dihydroxyflavanone; disaccharide derivative; flavanone glycoside; monomethoxyflavanone; rutinoside	mutagen
glycosides [no description available]	2.15	1
darutigenol darutigenol: from Siegesbeckia glabrescens Mak; structure given in first source	1.97	1
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	2.1	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
kirenol kirenol: an antirheumatic agent isolated from Siegebeckia; structure in first source	7.53	2	diterpenoid

Condition	Relationship Strength	Studies
Anasarca [description not available]	2.31	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.31	1
Breast Cancer [description not available]	2.15	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.15	1

chemdatabank.com