Page last updated: 2024-12-07
chrysanthemol
Description
Chrysanthemol is a naturally occurring sesquiterpene alcohol found in chrysanthemums and other plants. It exhibits a range of biological activities, including insecticidal, antifungal, and antioxidant properties. Chrysanthemol is synthesized through the mevalonate pathway, a key metabolic route for the production of terpenoids in plants. Its insecticidal activity is attributed to its disruption of insect nervous system function. Chrysanthemol is also studied for its potential therapeutic applications, such as its anti-inflammatory and wound-healing properties. Its importance lies in its natural origin, bioactivity, and potential for development as a sustainable and eco-friendly pesticide and pharmaceutical agent.'
chrysanthemol: a trans-eudesmane type sesquiterpene from flowers of Chrysanthemum indicum L.; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Chrysanthemum | genus | A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| Chrysanthemum indicum | species | [no description available] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| Chrysanthemum indicum | species | [no description available] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 110685 |
| CHEMBL ID | 1318346 |
| CHEBI ID | 81217 |
| SCHEMBL ID | 522961 |
| MeSH ID | M0157536 |
Synonyms (49)
| Synonym |
|---|
| DIVK1C_006433 |
| KBIO1_001377 |
| SDCCGMLS-0066572.P001 |
| SPECTRUM_001321 |
| SPECTRUM4_001654 |
| SPECTRUM5_000527 |
| chrysanthemyl alcohol |
| BSPBIO_003083 |
| NCGC00095607-01 |
| 5617-92-5 |
| KBIO3_002303 |
| KBIO2_006937 |
| KBIOGR_002147 |
| KBIO2_004369 |
| KBIOSS_001801 |
| KBIO2_001801 |
| SPECPLUS_000337 |
| SPBIO_001635 |
| SPECTRUM2_001768 |
| SPECTRUM3_001332 |
| SPECTRUM300566 |
| NCGC00095607-02 |
| chrysanthemol |
| C17611 |
| [2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropyl]methanol |
| chebi:81217 , |
| CHEMBL1318346 |
| CCG-38818 |
| unii-r52deg7bxk |
| ai3-20836 |
| cyclopropanemethanol, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (cis,trans-(+/-))- |
| einecs 227-045-0 |
| 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanemethanol |
| r52deg7bxk , |
| AKOS015910737 |
| SCHEMBL522961 |
| trans-chrysanthemyl alcohol |
| cyclopropanemethanol, 2,2-dimethyl-3-(2-methyl-1-propenyl)- |
| HIPIENNKVJCMAP-UHFFFAOYSA-N |
| [2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl]methanol # |
| cyclopropanemethanol,2,2-dimethyl-3-(2-methyl-1-propen-1-yl)-,(1r,3s)-rel- |
| mfcd00001305 |
| sr-05000002388 |
| SR-05000002388-1 |
| [2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropyl]methanol |
| Q27155163 |
| DTXSID10971555 |
| HY-N9493 |
| CS-0181924 |
Drug Classes (4)
| Class | Description |
|---|
| monoterpenoid | Any terpenoid derived from a monoterpene. The term includes compounds in which the C10 skeleton of the parent monoterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). |
| cyclopropanes | Cyclopropane and its derivatives formed by substitution. |
| homoallylic alcohol | An aliphatic alcohol where the hydroxy carbon is beta to a double bond. |
| primary alcohol | A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein Targets (2)
Potency Measurements
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 81.94
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 81.94 (24.57) | | Research Supply Index | 2.40 (2.92) | | Research Growth Index | 5.37 (4.65) | | Search Engine Demand Index | 206.92 (26.88) | | Search Engine Supply Index | 3.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (10.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (90.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |