| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1440810 | Stability of the compound in biochemical assay buffer under basic mobile phase conditions by HPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440809 | Stability of the compound in biochemical assay buffer under mildly acidic mobile phase conditions by HPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440781 | Half life in human liver microsomes up to 100 uM preincubated for 10 mins followed by NADPH addition by UPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440787 | Fraction unbound in human plasma | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440807 | Inhibition of dCTPase 1 in human HL60 cells assessed as potentiation of 0.5 to 10 uM 5-AzaC-induced cytotoxicity by measuring decrease in cell viability after 72 hrs by resazurin assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440777 | Inhibition of recombinant human N-terminal His-tagged dCTPase 1 expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by malachite green reagent based assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440785 | Hepatic extraction ratio in mouse liver microsomes up to 100 uM preincubated for 10 mins followed by NADPH addition by UPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440786 | Metabolic stability in human plasma after 4 hrs | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440783 | Kinetic solubility of the compound | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440779 | Binding affinity to recombinant human N-terminal His-tagged dCTPase 1 expressed in Escherichia coli BL21(DE3)pLysS assessed as change in melting temperature at 33 uM by Sypro Orange dye based DSF assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440806 | Cytotoxicity against human HL60 cells assessed as decrease in cell viability at 1 to 5 uM after 72 hrs by resazurin assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440805 | Inhibition of dCTPase 1 in human HL60 cells assessed as potentiation of 5-AzaC-induced cytotoxicity by measuring decrease in cell viability at 1 to 5 uM after 72 hrs by resazurin assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440780 | Half life in mouse liver microsomes up to 100 uM preincubated for 10 mins followed by NADPH addition by UPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440778 | Stability of the compound in DMSO measured after several months by HPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440788 | Intracellular bioavailability in human HL60 cells assessed as ratio of fraction unbound in cells to intracellular drug accumulation at 0.5 uM after 45 mins by LC-MS/MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| AID1440784 | Hepatic extraction ratio in human liver microsomes up to 100 uM preincubated for 10 mins followed by NADPH addition by UPLC-MS analysis | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |