| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1061995 | Inhibition of PPARdelta (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061992 | Inhibition of ETA receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061984 | Half life in rat at 1 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061985 | Blood clearance in rat at 1 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061986 | Cmax in rat at 2 mg/kg, po | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061988 | Free plasma concentration in rat | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061991 | Inhibition of ETB receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1062000 | Inhibition of GPR40 (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061987 | Intrinsic clearance in rat | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061982 | Oral bioavailability in rat at 2 mg/kg | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061994 | Inhibition of EP1 receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061993 | Inhibition of AT1 receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061996 | Inhibition of NTR1 receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1475129 | Permeability in MDCK cells expressing human MDR1 at 0.5 uM after 150 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. |
| AID1061998 | Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintillation proximity assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1475127 | Displacement of [3H]-neurotensin from human His6-tagged sortilin pretreated for 30 mins followed by [3H]-neurotensin addition after 6 hrs measured for 360 secs by SPA | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. |
| AID1061990 | Inhibition of MMP12 (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061999 | Inhibition of delta opioid receptor (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061989 | Solubility of the compound | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID1061983 | Volume of distribution at steady state in rat at 1 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |