neurotensin receptor activity, non-G protein-coupled

Definition

Target type: molecularfunction

Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. [GOC:mah, GOC:signaling, PMID:9756851]

Neurotensin receptor activity, non-G protein-coupled, refers to the ability of a protein to bind and respond to the neuropeptide neurotensin, but without activating a G protein signaling pathway. This receptor subtype, known as sortilin, is involved in various cellular processes, including:

* **Protein trafficking and sorting:** Sortilin acts as a sorting receptor, directing proteins to their correct cellular compartments, such as lysosomes and endosomes. It plays a crucial role in regulating the trafficking and degradation of a wide range of proteins, including neurotensin itself.

* **Neurotransmission:** While not directly coupled to G proteins, sortilin can indirectly influence neurotransmission by modulating the levels of neurotransmitters at the synapse. It does this by regulating the expression and activity of other proteins involved in neurotransmission.

* **Cell survival and apoptosis:** Sortilin has been implicated in regulating cell survival and apoptosis. Studies suggest that it can promote cell survival under certain conditions, while in other contexts, it may contribute to cell death.

* **Metabolic regulation:** Sortilin has been linked to metabolic processes, particularly those involved in lipid metabolism. It may regulate the expression of enzymes involved in lipid synthesis and degradation.

* **Development and differentiation:** Sortilin plays a role in various developmental processes, including neuronal differentiation and brain development.

* **Other cellular processes:** Sortilin is involved in a variety of other cellular functions, including cell adhesion, migration, and immune response.

The precise mechanisms by which sortilin exerts these diverse functions are still under investigation. However, it is clear that this non-G protein-coupled neurotensin receptor plays a vital role in regulating a wide range of cellular processes, contributing to its involvement in various physiological and pathological conditions.'
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Proteins (1)

Compounds (3)