| Assay ID | Title | Year | Journal | Article |
|---|
| AID1891869 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 8 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID417971 | Acute antihypertensive activity in two-kidney one-clip renal hypertensive rat assessed as reduction in systolic arterial pressure at 100 mg/kg/day | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417972 | Acute antihypertensive activity in two-kidney one-clip renal hypertensive rat assessed as reduction in diastolic arterial pressure at 100 mg/kg/day | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891866 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 2 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID1891867 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 4 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID417978 | Inhibition of pig lung ACE at 100 nmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID717089 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction of diastolic arterial pressure at 40 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry, Dec-01, Volume: 20, Issue:23
| Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity. |
| AID417976 | Inhibition of pig lung ACE at 10 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702934 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in systolic arterial pressure at 80 mg/kg, po measured up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
| Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417977 | Inhibition of pig lung ACE at 1 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702932 | Toxicity in spontaneously hypertensive rat assessed as change in basal heart rate at 50 mg/kg, po measured up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
| Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417975 | Inhibition of pig lung ACE at 100 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417979 | Inhibition of pig lung ACE at 10 nmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702936 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in diastolic arterial pressure at 80 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
| Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417980 | Inhibition of pig lung ACE at 100 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891868 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 6 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID702931 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in mean arterial pressure at 80 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
| Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417981 | Inhibition of pig lung ACE at 10 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417982 | Inhibition of pig lung ACE at 1 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891865 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 1 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |