Page last updated: 2024-11-13
7,8-dihydroxy-3-methylisochroman-4-one
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
7,8-dihydroxy-3-methylisochroman-4-one: has antihypertensive activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 25256788 |
| CHEMBL ID | 492368 |
| MeSH ID | M000597499 |
Synonyms (6)
| Synonym |
|---|
| CHEMBL492368 |
| 7,8-dihydroxy-3-methylisochroman-4-one |
| CS-0499235 |
| DTXSID101237257 |
| 7,8-dihydroxy-3-methyl-1h-2-benzopyran-4(3h)-one |
| 945619-75-0 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (20)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1891869 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 8 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID417971 | Acute antihypertensive activity in two-kidney one-clip renal hypertensive rat assessed as reduction in systolic arterial pressure at 100 mg/kg/day | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417972 | Acute antihypertensive activity in two-kidney one-clip renal hypertensive rat assessed as reduction in diastolic arterial pressure at 100 mg/kg/day | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891866 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 2 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID1891867 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 4 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID417978 | Inhibition of pig lung ACE at 100 nmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID717089 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction of diastolic arterial pressure at 40 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry, Dec-01, Volume: 20, Issue:23 | Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity. |
| AID417976 | Inhibition of pig lung ACE at 10 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702934 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in systolic arterial pressure at 80 mg/kg, po measured up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417977 | Inhibition of pig lung ACE at 1 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702932 | Toxicity in spontaneously hypertensive rat assessed as change in basal heart rate at 50 mg/kg, po measured up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417975 | Inhibition of pig lung ACE at 100 umol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417979 | Inhibition of pig lung ACE at 10 nmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID702936 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in diastolic arterial pressure at 80 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417980 | Inhibition of pig lung ACE at 100 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891868 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 6 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| AID702931 | Antihypertensive activity in spontaneously hypertensive rat assessed as reduction in mean arterial pressure at 80 mg/kg, po up to 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417981 | Inhibition of pig lung ACE at 10 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID417982 | Inhibition of pig lung ACE at 1 pmol/L assessed as enzyme restrain rate | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6 | Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4. |
| AID1891865 | Antihypertensive activity in spontaneous hypertensive rat model assessed as systolic blood pressure at 80 mg/kg, po measured after 1 hr by tail cuff method (Rvb = 186.1 +/- 4.6 mmHg) | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.18
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.18) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||