7-8-dihydroxy-3-methylisochroman-4-one and Hypertension--Renal

7-8-dihydroxy-3-methylisochroman-4-one has been researched along with Hypertension--Renal* in 1 studies

Other Studies

1 other study(ies) available for 7-8-dihydroxy-3-methylisochroman-4-one and Hypertension--Renal

ArticleYear
Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4.
    Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

    This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive activity in renal hypertensive rats and further mechanism studies revealed that it is an ACE inhibitor.

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Chemistry, Pharmaceutical; Chromones; Drug Design; Hypertension, Renal; Liver; Models, Chemical; Molecular Structure; Musa; Plant Extracts; Rats; Structure-Activity Relationship

2009