2,2',3,5,5',6-hexachlorobiphenyl
2,2',3,5,5',6-hexachlorobiphenyl (PCB 153) is a persistent organic pollutant (POP) and one of the most prevalent congeners in the environment. It is a colorless, odorless, and crystalline solid with a high melting point. PCB 153 is highly resistant to degradation and can persist in the environment for decades, accumulating in the food chain. It has been shown to have adverse effects on human health, including endocrine disruption, reproductive toxicity, and developmental neurotoxicity. Studies on PCB 153 focus on understanding its environmental fate, toxicology, and potential for bioaccumulation. It is also studied as a model compound for investigating the effects of PCB exposure on various biological processes.'
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Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 40471 |
| SCHEMBL ID | 4453366 |
| MeSH ID | M0182937 |
Synonyms (25)
| Synonym |
|---|
| 2,3,5,6,2',5'-hexachlorobiphenyl |
| 1,1'-biphenyl, 2,2',3,5,5',6-hexachloro- |
| inchi=1/c12h4cl6/c13-5-1-2-7(14)6(3-5)10-11(17)8(15)4-9(16)12(10)18/h1-4 |
| pcb no 151 |
| 1,2,4,5-tetrachloro-3-(2,5-dichlorophenyl)benzene |
| 2,2',3,5,5',6-hcbp |
| 52663-63-5 |
| r846435e65 , |
| unii-r846435e65 |
| 2,2',3,5,5',6-hexachlorobiphenyl |
| pcb 151 |
| 1,1'-biphenyl, 2,3,5,6,2',5'-hexachloro- |
| AKOS015903530 |
| pcb-151 |
| SCHEMBL4453366 |
| UHCLFIWDCYOTOL-UHFFFAOYSA-N |
| 2,2',3,5,5',6-hexachloro-1,1'-biphenyl |
| DTXSID2074160 , |
| pcb no 151, analytical standard |
| pcb no. 151 10 microg/ml in isooctane |
| 7,8,9,10-tetrahydro-6h-cyclohepta[b]quinoline-11-carboxylicacid |
| pcb no. 151 |
| Q27287953 |
| 2,2',3,5,5',6-hexachlorbiphenyl |
| dtxcid4041236 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to elucidate the effects of PCB153 on the biosynthesis, biotransformation, regulation, metabolism, and transport of thyroid hormones (THs), Sprague-Dawley (SD) rats were dosed with PCB153 intraperitoneally (i." | ( PCB153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism. Liu, C; Quan, C; Wang, C; Yan, M; Yang, K; Zhou, J, 2012) | 0.38 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.13
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.13) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||