Compounds > 2-(5-ethylpyridin-2-yl)benzimidazole
Page last updated: 2024-11-06

2-(5-ethylpyridin-2-yl)benzimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(5-ethylpyridin-2-yl)benzimidazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID49746
CHEMBL ID162115
SCHEMBL ID1248646
MeSH IDM0104203

Synonyms (24)

Synonym
kb-1043
benzimidazole, 2-(5-ethyl-2-pyridyl)-
2-(5-ethyl-2-pyridyl)benzimidazole
einecs 266-627-9
2-(5-ethyl-2-pyridinyl)-1h-benzimidazole
kb 1043
brn 0521180
2-(5-ethylpyridin-2-yl)benzimidazole
1h-benzimidazole, 2-(5-ethyl-2-pyridinyl)-
OPREA1_211055 ,
OPREA1_844741
2-(5-ethylpyridin-2-yl)-1h-benzimidazole
CHEMBL162115 ,
67273-43-2
AKOS024322566
SCHEMBL1248646
2-(5-ethylpyridin-2-yl) benzimidazol
2-(5-ethylpyridin-2-yl)-benzimidazole
2-(5-ethylpyridin-2-yl)benzimidazol
1h-benzimidazole, 2-(5-ethyl-2-pyridyl)-
2-(5-ethyl-2-pyridinyl)-1h-benzimidazole #
DTXSID6070487
2-(5-ethyl-pyridin-2-yl)-1h-benzoimidazole
bdbm50222214
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)IC50 (µMol)76.00000.00291.786810.0000AID160905
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)IC50 (µMol)76.00000.00291.823210.0000AID160905
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID160905Compound was tested for inhibition of prostaglandin synthetase when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID177363Compound was tested for inhibition of carrageenan induced edema when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID189994Compound was tested for ulcerogenicity when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID177365Compound was tested for inhibition of scald edema when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID181270Compound was tested for anti-pyrexia (Yeast-induced pyrexia) when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID107284Compound was evaluated for analgesia at 100 mg/kg when administered perorally (+ = positive mice >/=2)1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID194095Antiinflammatory activity was evaluated by contund edema after 3 hr at 200 mg/kg concentration administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID116913Compound was tested for acute toxicity when administered intraperitoneally in mice1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID116899Compound was evaluated for lethal dose in mice when administarted intraperitoneally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID177364Compound was tested for inhibition of contund edema when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID194094Antiinflammatory activity was evaluated by carrageenan-induced rat paw edema assay after 3 hr at 100 mg/kg concentration administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
AID178136Compound was tested for analgesia by Acetic acid writhing method when administered perorally1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenylbutazone
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.. phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.		1.9510pyrazolidinesantirheumatic drug;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug
2-(2'-pyridyl)benzimidazole
2-(2'-pyridyl)benzimidazole: structure in first source		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.3620
Gastric Ulcer
[description not available]		02.3620
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.3620
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.3620
Extravascular Hemolysis
[description not available]		01.9610
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		01.9610
Adjuvant Arthritis
[description not available]		01.9610
Granulomas
[description not available]		01.9610
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		01.9610
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.		01.9610