Compounds > primisulfuron
Page last updated: 2024-12-07

primisulfuron

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Primisulfuron is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS), an enzyme essential for the biosynthesis of branched-chain amino acids in plants. Its synthesis involves multiple steps, starting from 2-chloro-4-trifluoromethylpyrimidine. Primisulfuron is highly effective in controlling broadleaf weeds in various crops, including cereals, soybeans, and cotton. It is widely studied due to its selectivity, persistence in soil, and potential environmental impact. Studies on primisulfuron focus on its mode of action, efficacy, and potential for resistance development in weeds. It is also studied for its potential effects on non-target organisms and its fate in the environment.'

primisulfuron: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91774
CHEMBL ID2251449
CHEBI ID82031
SCHEMBL ID54482
MeSH IDM0368608

Synonyms (20)

Synonym
primisulfuron
2-[[4,6-bis(difluoromethoxy)pyrimidin-2-yl]carbamoylsulfamoyl]benzoic acid
113036-87-6
C18883
primisulfuron [iso]
7ufu80lx99 ,
benzoic acid, 2-(((((4,6-bis(difluoromethoxy)-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-
unii-7ufu80lx99
AKOS015900311
SCHEMBL54482
chebi:82031 ,
CHEMBL2251449
2-(((((4,6-bis(difluoromethoxy)-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)benzoic acid
2-(4,6-bis(difluoromethoxy)pyrimidin-2-ylcarbamoylsulfamoyl)benzoic acid
DTXSID40150270
benzoic acid, 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]-
2-(n-(4,6-bis(difluoromethoxy)pyrimidin-2-ylcarbamoyl)sulfamoyl)benzoic acid
FT-0725480
Q27155699
benzoic acid,2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]-

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Whole plant dose-response studies confirmed a 4- to the 12-fold level of primisulfuron resistance in three shattercane biotypes compared with the known primisulfuron-susceptible shattercane biotype."( Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides.
Bernards, M; Dweikat, IM; Gelli, M; Jhala, A; Martin, A, 2023)		1.14
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzoic acidsAny aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.23 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index24.97 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (22.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0210monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		4.0440isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ethylene
Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges		2.0210alkene;
gas molecular entity		plant hormone;
refrigerant
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.0210cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
bromoxynil
bromoxynil: RN given refers to parent cpd; structure. 3,5-dibromo-4-hydroxybenzonitrile : A dibromobenzene that is 2,6-dibromophenol substituted by a cyano group at position 4.		2.0210dibromobenzene;
hydroxynitrile;
phenols		environmental contaminant;
herbicide;
xenobiotic
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.0210benzenes;
phenyl acetates
prosulfuron
prosulfuron: structure in first source		2.0210triazines
methyl jasmonate
[no description available]		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Albinism
General term for a number of inherited defects of amino acid metabolism in which there is a deficiency or absence of pigment in the eyes, skin, or hair.		03.0110
Retinal Diseases
Diseases involving the RETINA.		03.0110