(3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone is a chemical compound that is sometimes referred to as **Trizol**. It's not a very common name, and it's important to understand that it's **not** the same thing as the popular reagent **Trizol**, which is used for RNA isolation.
The compound you're asking about is a **synthetic molecule** with a specific structure. This structure is characterized by:
* **A 1,2,4-triazole ring:** This is a five-membered heterocyclic ring containing three nitrogen atoms.
* **An amino group (NH2):** This group is attached to the 3-position of the triazole ring.
* **A carbonyl group (C=O):** This group is connected to the 4-position of the triazole ring.
* **A 2,5-dimethylphenyl group:** This is a benzene ring with two methyl groups attached at the 2 and 5 positions.
**Importance for Research:**
The specific importance of (3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone depends on its **properties and potential applications.** It's likely that this compound has been synthesized and studied for the following reasons:
* **Biological Activity:** The presence of the triazole ring and the amino group often suggests potential biological activity. It could act as a **ligand** for a specific receptor or enzyme, leading to pharmacological effects.
* **Synthetic Building Block:** The compound could be used as a **building block** for synthesizing more complex molecules with desired properties.
* **Material Science:** The triazole ring is known for its applications in **material science**, particularly in coordination chemistry and polymer synthesis.
**To know the specific importance of this compound, you need more information.** You should search for research papers or databases related to this molecule.
**Here are some search terms you can use:**
* (3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone
* Trizol (but be careful to distinguish it from the RNA isolation reagent)
* 1,2,4-triazole derivatives
* 2,5-dimethylphenyl derivatives
By searching with these terms, you can find relevant research articles and gain a better understanding of the compound's importance in research.
ID Source | ID |
---|---|
PubMed CID | 925484 |
CHEMBL ID | 1531593 |
CHEBI ID | 120470 |
Synonym |
---|
SDCCGMLS-0043929.P002 |
MLS000064102 , |
smr000075949 |
4-(2,5-dimethylbenzoyl)-4h-1,2,4-triazol-3-amine |
CHEBI:120470 |
KUC106704N |
ksc-11-212-14 |
(3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone |
HMS2336D03 |
(3-azanyl-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone |
cid_925484 |
bdbm45392 |
CHEMBL1531593 |
Q27208316 |
SR-01000273448-1 |
sr-01000273448 |
Class | Description |
---|---|
benzoic acids | Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
TDP1 protein | Homo sapiens (human) | Potency | 29.0929 | 0.0008 | 11.3822 | 44.6684 | AID686979 |
survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.8489 | 0.1259 | 12.2344 | 35.4813 | AID1458 |
Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1.0000 | 10.4756 | 28.1838 | AID901 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Coagulation factor XII | Homo sapiens (human) | IC50 (µMol) | 10.9666 | 0.0104 | 3.8890 | 10.9666 | AID852 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
serine-type endopeptidase activity | Coagulation factor XII | Homo sapiens (human) |
calcium ion binding | Coagulation factor XII | Homo sapiens (human) |
protein binding | Coagulation factor XII | Homo sapiens (human) |
misfolded protein binding | Coagulation factor XII | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular region | Coagulation factor XII | Homo sapiens (human) |
extracellular space | Coagulation factor XII | Homo sapiens (human) |
plasma membrane | Coagulation factor XII | Homo sapiens (human) |
collagen-containing extracellular matrix | Coagulation factor XII | Homo sapiens (human) |
extracellular exosome | Coagulation factor XII | Homo sapiens (human) |
extracellular space | Coagulation factor XII | Homo sapiens (human) |
rough endoplasmic reticulum | Coagulation factor XII | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |