3'-phosphoadenosine 5'-phosphosulfate binding

Definition

Target type: molecularfunction

Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]

3'-Phosphoadenosine 5'-phosphosulfate (PAPS) binding is a critical molecular function involved in various cellular processes, particularly those related to sulfate metabolism. PAPS serves as the universal sulfate donor in a wide range of sulfation reactions, including the modification of proteins, lipids, carbohydrates, and steroids. The binding of PAPS to its target enzymes, known as sulfotransferases, is essential for their catalytic activity. These enzymes catalyze the transfer of a sulfate group from PAPS to specific substrates, leading to a diverse range of biological effects. The binding of PAPS to sulfotransferases typically involves multiple interactions, including hydrogen bonding, electrostatic interactions, and hydrophobic contacts. These interactions contribute to the specificity and efficiency of the enzymatic reaction. The binding of PAPS to sulfotransferases can be regulated by various factors, including the concentration of PAPS, the presence of cofactors, and the phosphorylation state of the enzyme. This regulation ensures that sulfation occurs at the appropriate time and location within the cell. The molecular function of PAPS binding is therefore essential for maintaining cellular homeostasis and regulating diverse biological processes.'
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Proteins (3)

Compounds (18)