IgE binding

Definition

Target type: molecularfunction

Binding to an immunoglobulin of the IgE isotype. [GOC:add, ISBN:0781735149]

Immunoglobulin E (IgE) binding is a complex molecular interaction that plays a crucial role in allergic responses. IgE, a type of antibody, is produced by plasma cells upon sensitization to an allergen. It binds with high affinity to its cognate receptor, FcεRI, which is expressed on the surface of mast cells, basophils, and some eosinophils.

This binding event triggers a cascade of intracellular signaling events that ultimately lead to the release of inflammatory mediators such as histamine, leukotrienes, and cytokines. These mediators are responsible for the characteristic symptoms of allergic reactions, including sneezing, itching, swelling, and airway constriction.

The molecular basis of IgE binding to FcεRI involves several key features. First, IgE possesses a unique structure that allows it to interact with FcεRI with high affinity. This high affinity is due to a combination of electrostatic interactions, hydrogen bonds, and van der Waals forces. Second, FcεRI is a multimeric receptor composed of four subunits (α, β, γ2). The α chain binds to IgE, while the β and γ2 chains are involved in signaling.

The interaction between IgE and FcεRI is highly specific and involves a precise fit between the two molecules. This specificity is critical for ensuring that IgE does not bind to other receptors or molecules in the body.

The molecular function of IgE binding is therefore not limited to a single event. It is a complex interplay of events involving specific receptor-ligand interactions, conformational changes, and signal transduction pathways that ultimately result in the release of inflammatory mediators and the manifestation of allergic symptoms.'
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Proteins (2)

Compounds (12)