Page last updated: 2024-10-24

nitrogen compound transport

Definition

Target type: biologicalprocess

The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]

Nitrogen compound transport encompasses a diverse set of processes crucial for life, involving the movement of nitrogen-containing molecules across cellular membranes and within organisms. This intricate network of pathways facilitates nutrient uptake, waste removal, and the biosynthesis of essential biomolecules.

**1. Uptake and Assimilation:**

* **Nitrogen fixation:** The conversion of atmospheric nitrogen (N2) into usable forms like ammonia (NH3) by nitrogen-fixing microorganisms is a vital step in the nitrogen cycle. These organisms possess the enzyme nitrogenase, which catalyzes this energy-intensive reaction.
* **Nitrate (NO3-) uptake:** Plants and many microorganisms can absorb nitrate from the soil or water. Nitrate reductase enzymes convert nitrate into nitrite (NO2-), which is then further reduced to ammonia by nitrite reductase.
* **Ammonia (NH3) uptake:** Ammonia is readily absorbed by organisms and used for the synthesis of amino acids and other nitrogen-containing molecules.

**2. Intracellular Transport:**

* **Amino acid transport:** Amino acids are transported across cellular membranes through specific transporter proteins, ensuring their delivery to the appropriate compartments for protein synthesis and other metabolic processes.
* **Nitrogenous waste transport:** Excess nitrogenous waste products, such as urea and uric acid, need to be efficiently removed from the body. Specialized transporters facilitate their movement to the kidneys or other excretory organs.

**3. Intercellular Transport:**

* **Long-distance transport in plants:** In vascular plants, nitrogen compounds are transported through the xylem and phloem, ensuring their distribution from roots to shoots and other tissues.
* **Hormonal transport:** Some nitrogen-containing compounds act as hormones, regulating various physiological processes. Their transport throughout the body is essential for proper function.

**4. Extracellular Transport:**

* **Nitrogen cycling in ecosystems:** Decomposers break down organic matter, releasing nitrogen back into the environment, where it can be taken up by other organisms.
* **Nitrogen loss from ecosystems:** Certain processes, like denitrification, lead to the loss of nitrogen from ecosystems, often converting nitrate into nitrogen gas that escapes into the atmosphere.

In summary, nitrogen compound transport encompasses a wide range of mechanisms that ensure the efficient uptake, assimilation, and distribution of nitrogen-containing molecules, contributing to the fundamental processes of life.'
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Proteins (4)

ProteinDefinitionTaxonomy
Sodium- and chloride-dependent GABA transporter 2A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSD5]Homo sapiens (human)
Sodium- and chloride-dependent GABA transporter 2A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSD5]Homo sapiens (human)
Sodium- and chloride-dependent creatine transporter 1A sodium- and chloride-dependent creatine transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48029]Homo sapiens (human)
Sodium- and chloride-dependent taurine transporterA sodium- and chloride-dependent taurine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31641]Homo sapiens (human)

Compounds (11)

CompoundDefinitionClassesRoles
gamma-aminobutyric acidgamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid
human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
beta-alanineamino acid zwitterion;
beta-amino acid
agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
2,3-diaminopropionic acid3-aminoalanine : A diamino acid that is alanine in which one of the hydrogens of the methyl group is replaced by an amino group.alanine derivative;
amino acid zwitterion;
beta-amino acid;
diamino acid;
non-proteinogenic alpha-amino acid
Escherichia coli metabolite
creatineglycine derivative;
guanidines;
zwitterion
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
taurineamino sulfonic acid;
zwitterion
antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
guvacineguvacine : A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.

guvacine: RN given refers to parent cpd
alpha,beta-unsaturated monocarboxylic acid;
beta-amino acid;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine
GABA reuptake inhibitor;
plant metabolite
nipecotic acidnipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.

nipecotic acid: RN given refers to cpd without isomeric designation
beta-amino acid;
piperidinemonocarboxylic acid
n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamideN-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide: inhibits the betaine-GABA transporter 1; structure in first source
2-ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamidepiperidines
nnc 05-2090NNC 05-2090: structure given in first sourcecarbazoles
snap 5114