Target type: biologicalprocess
The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). [GOC:ai]
Sensory perception of touch is a complex process that allows us to interact with the world around us. It involves a series of steps, starting with the detection of mechanical stimuli by specialized sensory receptors in the skin called mechanoreceptors. These receptors are located in different layers of the skin, each sensitive to different types of pressure, vibration, and texture.
When a stimulus is applied to the skin, it deforms the mechanoreceptor, triggering a change in its membrane potential. This change in potential is then converted into an electrical signal, which is transmitted along a sensory nerve fiber to the spinal cord.
From the spinal cord, the signal travels up the ascending sensory pathways to the brainstem and ultimately to the somatosensory cortex, the part of the brain responsible for processing sensory information.
There are different types of mechanoreceptors, each with its own specific function:
* **Merkel cells:** These receptors are located in the epidermis and are responsible for detecting sustained pressure and fine details, like texture.
* **Meissner corpuscles:** These receptors are found in the dermis and are responsible for detecting light touch and vibrations.
* **Pacinian corpuscles:** These receptors are also located in the dermis and are responsible for detecting rapid vibrations and pressure changes.
* **Ruffini endings:** These receptors are located in the dermis and are responsible for detecting stretching and pressure.
The information from these receptors is integrated in the somatosensory cortex, allowing us to perceive the characteristics of the stimulus, such as its location, intensity, and texture. This perception is further influenced by our previous experiences and expectations.
The sense of touch is essential for many everyday activities, including walking, grasping objects, and feeling pain. It also plays a crucial role in social interaction, as touch is an important way to communicate emotions and affection.
In addition to the mechanical stimuli, touch perception is also influenced by other factors, such as temperature and pain. These sensory modalities are also processed in the somatosensory cortex, allowing us to experience the full complexity of touch.'
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Protein | Definition | Taxonomy |
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P2X purinoceptor 4 | A P2X purinoceptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99571] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
carbamazepine | carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties. | dibenzoazepine; ureas | analgesic; anticonvulsant; antimanic drug; drug allergen; EC 3.5.1.98 (histone deacetylase) inhibitor; environmental contaminant; glutamate transporter activator; mitogen; non-narcotic analgesic; sodium channel blocker; xenobiotic |
carbamazepine epoxide | carbamazepine epoxide: metabolite of carbamazepine; RN given refers to unlabeled cpd carbamazepine-10,11-epoxide : An epoxide and metabolite of carbamazepine. | dibenzoazepine; epoxide; ureas | allergen; drug metabolite; marine xenobiotic metabolite |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid | 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid : An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6. pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid: a novel antagonist that selectively blocks P2 purinoceptor receptors; a useful tool to study co-transmission in tissues when ATP and coexisting neurotransmitters act in concert | arenesulfonic acid; azobenzenes; methylpyridines; monohydroxypyridine; organic phosphate; pyridinecarbaldehyde | purinergic receptor P2X antagonist |
10,11-dihydrocarbamazepine | |||
diadenosine tetraphosphate | P(1),P(4)-bis(5'-adenosyl) tetraphosphate : A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions. | diadenosyl tetraphosphate | Escherichia coli metabolite; mouse metabolite |
oxcarbazepine | oxcarbazepine : A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. Oxcarbazepine: A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4. | cyclic ketone; dibenzoazepine | anticonvulsant; drug allergen |
paroxetine | paroxetine : A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. Paroxetine: A serotonin uptake inhibitor that is effective in the treatment of depression. | aromatic ether; benzodioxoles; organofluorine compound; piperidines | antidepressant; anxiolytic drug; hepatotoxic agent; P450 inhibitor; serotonin uptake inhibitor |
9-chloroacridine | 9-chloroacridine: chromogenic reagent for detection of arylhydroxylamines & arylamines on paper & thin layer chromatograms; structure | ||
10-hydroxycarbamazepine | 10,11-dihydro-10-hydroxycarbamazepine: main metabolite of oxcarbazepine; structure given in first source licarbazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine. | carboxamide; dibenzoazepine; ureas | anticonvulsant; drug allergen; sodium channel blocker |
eslicarbazepine acetate | eslicarbazepine acetate : The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy. | acetate ester; carboxamide; dibenzoazepine; ureas | anticonvulsant; drug allergen |
1-(5H-dibenzo[b,f]azepin-5-yl)ethan-1-one | dibenzooxazepine | ||
8-azidoadenosine 5'-triphosphate | |||
6-thioinosine-5'-triphosphate | organic molecule | ||
imd 0354 | N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide: a cardioprotective agent that inhibits IkappaB kinase beta (IKKbeta); structure in first source | benzamides | |
2-methylthio-atp | 2-methylthio-ATP: purinergic receptors agonist; relaxes mammalian gut preparations; structure given in first source | ||
adp beta s | adenosine 5'-O-(2-thiodiphosphate): partial agonist toward platelet aggregation; see also record for 1-thiodiphosphate cpd | ||
kn 62 | KN 62: inhibitor of Ca/calmodulin-dependent protein kinase II | piperazines | |
nf023 | |||
af 353 | 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine: a P2X3 and P2X2/3 receptor antagonist; structure in first source |