Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. [GOC:mah, ISBN:0198506732]
Hyaluronan catabolic process is the breakdown of hyaluronan, a large, linear polysaccharide that is a major component of the extracellular matrix. This process is essential for tissue remodeling, wound healing, and inflammation. Hyaluronan is synthesized by hyaluronan synthases and degraded by hyaluronidases. Hyaluronidases are a family of enzymes that specifically cleave the glycosidic bonds within hyaluronan. There are several different types of hyaluronidases, each with a different substrate specificity and cellular localization. For example, hyaluronidase 1 (HYAL1) is a lysosomal enzyme that degrades hyaluronan to tetrasaccharides and disaccharides, while hyaluronidase 2 (HYAL2) is a membrane-bound enzyme that degrades hyaluronan to oligosaccharides. The breakdown of hyaluronan can be regulated by various factors, including growth factors, cytokines, and hormones. The products of hyaluronan catabolism, such as hyaluronan fragments, can have diverse biological activities, including modulating cell signaling, inflammation, and angiogenesis. These fragments can also be recognized by specific receptors on the cell surface, leading to the activation of downstream signaling pathways. Hyaluronan catabolic process is tightly regulated and plays a crucial role in maintaining tissue homeostasis and responding to various physiological and pathological conditions.'
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Protein | Definition | Taxonomy |
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Hyaluronidase-1 | A hyaluronidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12794] | Homo sapiens (human) |
Hyaluronidase-1 | A hyaluronidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12794] | Homo sapiens (human) |
CD44 antigen | A CD44 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16070] | Homo sapiens (human) |
Fibroblast growth factor 2 | A fibroblast growth factor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09038] | Homo sapiens (human) |
Beta-glucuronidase | A beta-glucuronidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08236] | Homo sapiens (human) |
Beta-hexosaminidase subunit beta | A beta-hexosaminidase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07686] | Homo sapiens (human) |
Beta-hexosaminidase subunit alpha | A beta-hexosaminidase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06865] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
pyrimethamine | Maloprim: contains above 2 cpds | aminopyrimidine; monochlorobenzenes | antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
dehydroepiandrosterone | dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands. Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. | 17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid | androgen; human metabolite; mouse metabolite |
1,2,3,4-tetrahydroisoquinoline | 1,2,3,4-tetrahydroisoquinoline: RN given refers to cpd with locants as specified | isoquinolines | |
naphthalimides | Naphthalimides: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS. | ||
methyl methanethiosulfinate | methyl methanethiosulfinate: structure in first source; a metabolite of S-methyl cysteine sulfoxide | sulfur oxoacid derivative | |
saccharolactone | D-glucaro-1,4-lactone : A delta-lactone that is D-glucono-1,4-lactone in which the hydroxy group at position 6 has been oxidised to the corresponding carboxylic acid. saccharolactone: used as index for assessing induction of hepatic enzymes by anticonvulsants; RN given refers to cpd without isomeric designation | aldarolactone; delta-lactone | |
2-acetamido-1,5-imino-1,2,5-trideoxy-d-glucitol | 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol: structure given in first source | ||
2-(2-oxolanylmethyl)benzo[de]isoquinoline-1,3-dione | isoquinolines | ||
ferulic acid | ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid. | ferulic acids | anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite |
2,2'-dihydroxychalcone | 2,2'-dihydroxychalcone: an antineoplastic agent; structure in first source | ||
caffeic acid | trans-caffeic acid : The trans-isomer of caffeic acid. | caffeic acid | geroprotector; mouse metabolite |
1-[4-[(2-methyl-4-quinolinyl)amino]phenyl]ethanone | aromatic ketone | ||
isoferulic acid | isoferulic acid : A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 4 and 3 respectively on the phenyl ring. isoferulic acid: isomer of ferulic acid; structure | ferulic acids | antioxidant; biomarker; metabolite |
kaempferol | 7-hydroxyflavonol; flavonols; tetrahydroxyflavone | antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite | |
mangiferin | shamimin: isolated from the leaves of Bombax ceiba; structure in first source | C-glycosyl compound; xanthones | anti-inflammatory agent; antioxidant; hypoglycemic agent; plant metabolite |
kuwanon g | kuwanon G: a non-peptide bombesin receptor antagonist; RN refers to (1S-(1alpha,5alpha,6beta))-isomer; structure given in first source kuwanone G : A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity. | resorcinols; tetrahydroxyflavone | anti-inflammatory agent; plant metabolite |
rosmarinic acid | (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid. rosmarinic acid: RN given refers to parent cpd; promote OT project | rosmarinic acid | geroprotector; plant metabolite |
n-acetylglucosamine thiazoline | N-acetylglucosamine thiazoline: an analog of the oxazolinium bicyclic intermediate leading from N-acetylglucosamine to 1,6-anhydro-N-acetylmuramic acid | ||
2',5'-dihydroxychalcone | 2',5'-dihydroxychalcone: structure given in first source | chalcones | |
ginkgolide b | |||
tivozanib | N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea: KNR-951 is the HCl, monohydrate salt; an antineoplastic agent; structure in first source | aromatic ether | |
b355252 | |||
phosphomannopentaose sulfate | phosphomannopentaose sulfate: structure in first source | ||
pg 545 | PG 545: an anti-angiogenesis agent with heparanase inhibitory activity; structure in first source | ||
2-(4-methoxyphenyl)-1H-quinazolin-4-one | quinazolines | ||
thiamet g |