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Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

An endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKM7]

Synonyms

EC 3.2.1.113;
ER alpha-1,2-mannosidase;
ER mannosidase 1;
ERMan1;
Man9GlcNAc2-specific-processing alpha-mannosidase;
Mannosidase alpha class 1B member 1

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
1,4-dideoxy-1,4-iminoarabinitol, (2r-(2alpha,3beta,4beta))-isomerHomo sapiens (human)Ki1.260011

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
mannosyl-oligosaccharide 1,2-alpha-mannosidase activitymolecular functionCatalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]

Located In

This protein is located in 7 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytoplasmic vesiclecellular componentA vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
endoplasmic reticulum quality control compartmentcellular componentA subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. [PMID:11408579]
extracellular vesiclecellular componentAny vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
mannoprotein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues. [ISBN:0198506732]
protein glycosylationbiological processA protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr]
oligosaccharide metabolic processbiological processThe chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]
viral protein processingbiological processAny protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. [GOC:bf, GOC:jl, ISBN:0781702534]
ERAD pathwaybiological processThe protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]
protein alpha-1,2-demannosylationbiological processThe removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655]
mannose trimming involved in glycoprotein ERAD pathwaybiological processThe removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD). [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]