Page last updated: 2024-12-08

E3040 glucuronide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

E3040 glucuronide : A member of the class of benzothiazoles that is E3040 in which the hydroxy hydrogen at position 6 has been replaced by a beta-D-glucosiduronic acid group. It is a metabolite of the anti-inflammatory drug, E3040. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID443294
CHEMBL ID2074599
CHEBI ID4733

Synonyms (12)

Synonym
C11595 ,
e3040 glucuronide
(2s,3s,4s,5r,6s)-6-[[5,7-dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)-1,3-benzothiazol-6-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
AC1L9EDW ,
bdbm50391002
chebi:4733 ,
CHEMBL2074599 ,
5,7-dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)-1,3-benzothiazol-6-yl beta-d-glucopyranosiduronic acid
e-3040 glucuronide
2-(methylamino)-5,7-dimethyl-4-(3-pyridinylmethyl)benzothiazole-6-yl beta-d-glucopyranosiduronic acid
(2s,3s,4s,5r,6s)-6-[[5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl]oxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
Q27106456
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
xenobiotic metaboliteAny metabolite produced by metabolism of a xenobiotic compound.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
beta-D-glucosiduronic acidA glucosiduronic acid resulting from the formal condensation of any substance with beta-D-glucuronic acid to form a glycosidic bond.
pyridinesAny organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
benzothiazoles
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
ATP-binding cassette sub-family C member 3Rattus norvegicus (Norway rat)Ki2.60002.60002.60002.6000AID682201
Canalicular multispecific organic anion transporter 1Rattus norvegicus (Norway rat)Ki3.84000.84004.968210.0000AID679036
Multidrug resistance associated proteinHomo sapiens (human)Ki5.60005.60005.60005.6000AID678977
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Canalicular multispecific organic anion transporter 1Rattus norvegicus (Norway rat)Km5.70001.50004.34206.9000AID679803
Canalicular multispecific organic anion transporter 1Homo sapiens (human)Km14.10007.20008.30009.4000AID679300
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
xenobiotic metabolic processCanalicular multispecific organic anion transporter 1Homo sapiens (human)
xenobiotic transmembrane transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
negative regulation of gene expressionCanalicular multispecific organic anion transporter 1Homo sapiens (human)
bile acid and bile salt transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
bilirubin transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
heme catabolic processCanalicular multispecific organic anion transporter 1Homo sapiens (human)
xenobiotic export from cellCanalicular multispecific organic anion transporter 1Homo sapiens (human)
transmembrane transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
transepithelial transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
leukotriene transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
monoatomic anion transmembrane transportCanalicular multispecific organic anion transporter 1Homo sapiens (human)
transport across blood-brain barrierCanalicular multispecific organic anion transporter 1Homo sapiens (human)
xenobiotic transport across blood-brain barrierCanalicular multispecific organic anion transporter 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
protein bindingCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ATP bindingCanalicular multispecific organic anion transporter 1Homo sapiens (human)
organic anion transmembrane transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ABC-type xenobiotic transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
bilirubin transmembrane transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ABC-type glutathione S-conjugate transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ATP hydrolysis activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ATPase-coupled transmembrane transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
xenobiotic transmembrane transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ATPase-coupled inorganic anion transmembrane transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
ABC-type transporter activityCanalicular multispecific organic anion transporter 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
plasma membraneCanalicular multispecific organic anion transporter 1Homo sapiens (human)
cell surfaceCanalicular multispecific organic anion transporter 1Homo sapiens (human)
apical plasma membraneCanalicular multispecific organic anion transporter 1Homo sapiens (human)
intercellular canaliculusCanalicular multispecific organic anion transporter 1Homo sapiens (human)
apical plasma membraneCanalicular multispecific organic anion transporter 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID682205TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.1 uM, E3040 glucuronide: 50 uM) in membrane vesicles from MRP3-expressing HeLa cells1999The Journal of biological chemistry, May-21, Volume: 274, Issue:21
Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).
AID678977TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicle from MRP3-expressing Sf9 cells2002Pharmaceutical research, Jan, Volume: 19, Issue:1
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
AID679036TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat1997The Journal of pharmacology and experimental therapeutics, Aug, Volume: 282, Issue:2
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
AID682129TP_TRANSPORTER: inhibition of E1S uptake by 6-hydroxy-5,7-dimetyl-2-metylamino-4-(3-pyridylmethyl) benzothiazole glucronid at a concentration of 250uM in membrane vesicles from ABCG2-expressing P388 cells2003The Journal of biological chemistry, Jun-20, Volume: 278, Issue:25
ABCG2 transports sulfated conjugates of steroids and xenobiotics.
AID679803TP_TRANSPORTER: uptake in bile canalicular membrane vesicles from SD rat1997The Journal of pharmacology and experimental therapeutics, Aug, Volume: 282, Issue:2
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
AID679140TP_TRANSPORTER: uptake in membrane vesicles from Mrp3-expressing Sf9 cells2002Pharmaceutical research, Jan, Volume: 19, Issue:1
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
AID679300TP_TRANSPORTER: uptake in bile canalicular membrane vesicles1999The American journal of physiology, 05, Volume: 276, Issue:5
Primary active transport of organic anions on bile canalicular membrane in humans.
AID681172TP_TRANSPORTER: uptake (vesicle) in membrane vesicles from ABCG2-expressing P388 cells2003The Journal of biological chemistry, Jun-20, Volume: 278, Issue:25
ABCG2 transports sulfated conjugates of steroids and xenobiotics.
AID682201TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicle from MRP3-expressing Sf9 cells2002Pharmaceutical research, Jan, Volume: 19, Issue:1
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
AID679478TP_TRANSPORTER: uptake in membrane vesicle from Mrp3-expressing LLC-PK1 cells1999The Journal of biological chemistry, May-21, Volume: 274, Issue:21
Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).
AID678976TP_TRANSPORTER: uptake in membrane vesicle from MRP3-expressing Sf9 cells2002Pharmaceutical research, Jan, Volume: 19, Issue:1
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]