4-fluoro-N-(3-pyridinyl)benzamide profile

ID Source	ID
PubMed CID	1118253
CHEMBL ID	1645407
CHEBI ID	93337
SCHEMBL ID	9808115

Synonym
smr000121532
MLS000529057
bdbm50334192
OPREA1_010781
OPREA1_842984
4-fluoro-n-pyridin-3-yl-benzamide
BAS 00628514
STK156746
4-fluoro-n-(pyridin-3-yl)benzamide
ZTZ252
AKOS000672783
AILCVPMYLXWTCO-UHFFFAOYSA-N
4-fluoro-n-(3-pyridinyl) benzamide
4-fluoro-n-(3-pyridinyl)benzamide
4-fluoro-n-pyridin-3-ylbenzamide
CHEMBL1645407 ,
HMS2329H13
SCHEMBL9808115
120737-99-7
CHEBI:93337
Q27165049
fpm_n
fpm_o
4-fluoro-n~1~-(3-pyridyl)benzamide

Class	Description
organohalogen compound	A compound containing at least one carbon-halogen bond (where X is a halogen atom).
carbonyl compound	Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	0.2818	0.0032	45.4673	12,589.2998	AID2517
67.9K protein	Vaccinia virus	Potency	22.3872	0.0001	8.4406	100.0000	AID720579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)	IC50 (µMol)	14.3000	0.0005	0.2902	2.7800	AID549715
Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)	IC50 (µMol)	0.0820	0.0001	0.2738	3.5000	AID549714
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
C21-steroid hormone biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
glucocorticoid biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
immune response	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
regulation of blood pressure	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
sterol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
aldosterone biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to hormone stimulus	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to potassium ion	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
glucose homeostasis	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol metabolic process	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cellular response to peptide hormone stimulus	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
regulation of blood volume by renal aldosterone	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
renal water homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
C21-steroid hormone biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mineralocorticoid biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
sterol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
aldosterone biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to hormone stimulus	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cortisol biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to potassium ion	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
potassium ion homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
sodium ion homeostasis	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
glucocorticoid biosynthetic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cortisol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cellular response to peptide hormone stimulus	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
steroid 11-beta-monooxygenase activity	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
iron ion binding	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
heme binding	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
corticosterone 18-monooxygenase activity	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
steroid 11-beta-monooxygenase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
iron ion binding	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
heme binding	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
corticosterone 18-monooxygenase activity	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
mitochondrion	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)
mitochondrion	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID549716	Selectivity ratio of IC50 for human steroid-11beta-hydroxylase to IC50 for human aldosterone synthase	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549714	Inhibition of human aldosterone synthase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549713	Inhibition of human steroid-11beta-hydroxylase expressed in chinese hamster V79 cells at 500 nM using 11-deoxycorticosterone as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549786	Inhibition of human placental CYP19 at 500 nM using androstenedione as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549712	Inhibition of human aldosterone synthase expressed in chinese hamster V79 cells at 500 nM using 11-deoxycorticosterone as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549715	Inhibition of human steroid-11beta-hydroxylase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
AID549784	Inhibition of human CYP17 expressed in Escherichia coli at 2000 nM using progesterone as substrate	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	4 (66.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.06	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
metyrapone Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.. metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.	2.06	1	aromatic ketone	antimetabolite; diagnostic agent; EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
fadrozole Fadrozole: A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.	2.06	1	imidazopyridine

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

4-fluoro-N-(3-pyridinyl)benzamide

Cross-References

Synonyms (24)

Drug Classes (2)

Protein Targets (4)

Potency Measurements

Inhibition Measurements

Biological Processes (18)

Molecular Functions (5)

Ceullar Components (2)

Bioassays (20)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.35

Study Types

4-fluoro-N-(3-pyridinyl)benzamide

Cross-References

Synonyms (24)

Drug Classes (2)

Protein Targets (4)

Potency Measurements

Inhibition Measurements

Biological Processes (18)

Molecular Functions (5)

Ceullar Components (2)

Bioassays (20)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.35

Study Types

Related Drugs (3)

Related Conditions (2)