2-(4-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile

2-(4-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile is a **chemical compound** with the molecular formula C11H8ClN3O. It is also known by its common name, **SAR1386**.

**Importance in Research:**

SAR1386 is a research chemical with potential **pharmacological activity**. Specifically, it has been studied for its role as a **potent and selective inhibitor of the enzyme glycogen synthase kinase 3 (GSK-3)**.

**GSK-3** is a serine/threonine protein kinase involved in various cellular processes, including:

* **Regulation of glycogen synthesis:** GSK-3 inhibits glycogen synthase, the enzyme responsible for glycogen synthesis.
* **Cell growth and differentiation:** GSK-3 plays a role in cell cycle regulation and apoptosis.
* **Neurotransmission:** GSK-3 is implicated in neurodegenerative diseases such as Alzheimer's disease.

**Research on SAR1386:**

Research on SAR1386 has focused on its potential therapeutic applications in the following areas:

* **Diabetes:** As an inhibitor of GSK-3, SAR1386 may help regulate blood sugar levels and improve insulin sensitivity.
* **Neurodegenerative diseases:** By inhibiting GSK-3, SAR1386 may protect against neuronal damage and potentially slow the progression of neurodegenerative diseases like Alzheimer's disease.
* **Cancer:** Some studies suggest that GSK-3 inhibitors may have anti-cancer properties by affecting cell growth and survival.

**Note:**

It's crucial to understand that SAR1386 is still in the **research phase** and is not currently approved for any medical use. Its safety and efficacy in humans have not been fully established.

Further research is needed to investigate its potential therapeutic applications and determine its safety profile before it can be considered for clinical use.