| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
n(1)-methylnicotinamide
N(1)-methylnicotinamide: RN given refers to parent cpd. 1-methylnicotinamide : A pyridinium ion comprising nicotinamide having a methyl group at the 1-position. It is a metabolite of nicotinamide which was initially considered to be biologically inactive but has emerged as an anti-thrombotic and anti-inflammatory agent. | 1.97 | 1 | 0 | pyridinium ion | algal metabolite;
anti-inflammatory agent;
human urinary metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4. | 2.37 | 2 | 0 | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin |
cetylpyridinium
Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges. | 1.97 | 1 | 0 | pyridinium ion | |
guanethidine
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.. guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.. guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid. | 1.97 | 1 | 0 | azocanes;
guanidines | adrenergic antagonist;
antihypertensive agent;
sympatholytic agent |
sk&f 29661
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide: structure | 2 | 1 | 0 | | |
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects. | 1.97 | 1 | 0 | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug |
1,2,3,4-tetrahydroisoquinoline
1,2,3,4-tetrahydroisoquinoline: RN given refers to cpd with locants as specified | 2.7 | 3 | 0 | isoquinolines | |
quinoline
[no description available] | 1.97 | 1 | 0 | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines | |
benzylamine
aminotoluene : Any member of the class of toluenes carrying one or more amino groups. | 2 | 1 | 0 | aralkylamine;
primary amine | allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite |
isoquinoline
[no description available] | 1.97 | 1 | 0 | azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene | |
nuciferine
nuciferine: CNS depressant; glutamic acid antagonist; RN given refers to (R)-isomer; structure | 2.08 | 1 | 0 | | |
1-methylpyridinium
1-methylpyridinium: RN given refers to parent cpd | 1.97 | 1 | 0 | methylpyridines | |
4-phenylpyridine
[no description available] | 1.97 | 1 | 0 | phenylpyridine | |
paraquat
Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.. paraquat : An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions. | 1.97 | 1 | 0 | organic cation | geroprotector;
herbicide |
1-methylquinolinium
1-methylquinolinium: RN given refers to parent cpd | 1.97 | 1 | 0 | | |
n-methylisoquinolinium
N-methylisoquinolinium: RN given refers to parent cpd; structure given in first source | 1.97 | 1 | 0 | | |
norsalsolinol
norsalsolinol: rigid dopamine analog; RN given refers to parent cpd; structure. norsalsolinol : An isoquinolinol that is 1,2,3,4-tetrahydroisoquinoline substituted by hydroxy groups at positions 6 and 7. It is present in the dopamine-rich areas of the human brain, including the substantia nigra. | 2 | 1 | 0 | isoquinolinol | animal metabolite;
apoptosis inducer;
human metabolite;
marine metabolite |
1-methyl-4-phenylpyridinium
1-Methyl-4-phenylpyridinium: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.. N-methyl-4-phenylpyridinium : A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position. | 1.97 | 1 | 0 | pyridinium ion | apoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin |
tenocyclidine
tenocyclidine : A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent. | 1.97 | 1 | 0 | piperidines;
tertiary amino compound;
thiophenes | central nervous system stimulant;
hallucinogen;
neuroprotective agent;
NMDA receptor antagonist |
1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroquinoline: structure in first source. 1,2,3,4-tetrahydroquinoline : A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline. | 1.97 | 1 | 0 | quinolines | |
1-phenethylamine, (s)-isomer
(1S)-1-phenylethanamine : The (S)-enantiomer of 1-phenylethanamine. | 2 | 1 | 0 | 1-phenylethylamine | |
4-phenyl-1,2,3,6-tetrahydropyridine
4-phenyl-1,2,3,6-tetrahydropyridine: RN given refers to parent cpd | 1.97 | 1 | 0 | | |
armepavine
[no description available] | 2.08 | 1 | 0 | | |
1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline
1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline: structure given in first source | 1.97 | 1 | 0 | benzyltetrahydroisoquinoline | |
1,2,3,4-tetrahydro-1-phenylisoquinoline
1,2,3,4-tetrahydro-1-phenylisoquinoline: structure in first source | 1.97 | 1 | 0 | | |
2-methyltryptoline
2-methyltryptoline: enzymatic preparation from human brain converts methyltyptamine to methyltryptoline; structure | 2.37 | 2 | 0 | beta-carbolines | |
ly 134046
LY 134046: RN given refers to parent cpd; structure in first source | 2 | 1 | 0 | | |
lysicamine
lysicamine: oxoaporphine alkaloid; structure in first source | 2.08 | 1 | 0 | alkaloid antibiotic;
oxoaporphine alkaloid | metabolite |
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline: potent reversible inhibitor of phenylethanolamine N-methyltransferase; structure. 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline : A 1,2,3,4-tetrahydroisoquinoline hacing chloro substituents at the 7- and 8-positions. | 2 | 1 | 0 | isoquinolines;
organochlorine compound | |
dizocilpine
[no description available] | 1.97 | 1 | 0 | secondary amino compound;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist |
pronuciferine
pronuciferine: alkaloid; structure in first source. (+)-pronuciferine : An isoquinoline alkaloid isolated from Berberis coletioides. | 2.08 | 1 | 0 | aromatic ether;
cyclic ketone;
isoquinoline alkaloid;
isoquinolines;
organic heterotetracyclic compound | plant metabolite |
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. | 2.08 | 1 | 0 | beta-D-glucoside;
monosaccharide derivative | Escherichia coli metabolite;
plant metabolite |
1-phenethylamine, (r)-isomer
(1R)-1-phenylethanamine : The (R)-enantiomer of 1-phenylethanamine. | 2 | 1 | 0 | 1-phenylethylamine | |
4-phenyl-1,2,3,4-tetrahydroisoquinoline
4-phenyl-1,2,3,4-tetrahydroisoquinoline: RN given is for (R)-isomer; inhibits spinal reflex-enhancing effects of methamphetamine, phenylethylamine, and nomifensine | 1.97 | 1 | 0 | isoquinolines | |
3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline: structure in first source | 2 | 1 | 0 | | |