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tyrosyl-prolyl-tryptophyl-glycinamide and morphine

tyrosyl-prolyl-tryptophyl-glycinamide has been researched along with morphine in 6 studies

Compound Research Comparison

Studies
(tyrosyl-prolyl-tryptophyl-glycinamide)
Trials
(tyrosyl-prolyl-tryptophyl-glycinamide)
Recent Studies (post-2010)
(tyrosyl-prolyl-tryptophyl-glycinamide)
Studies
(morphine)
Trials
(morphine)
Recent Studies (post-2010) (morphine)
250044,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomytyrosyl-prolyl-tryptophyl-glycinamide (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, SL; Hackler, L; Kastin, AJ; Zadina, JE1
Gergen, KA; Paul, D; Zadina, JE1
Harrison, LM; Kastin, AJ; Zadina, JE1
Bell, RL; Kastin, AJ; Nores, WL; Olson, GA; Olson, RD; Vaccarino, AL; Zadina, JE1
Bell, RL; Cambre, JG; Kastin, AJ; Nores, WL; Olson, GA; Olson, RD; Vaccarino, AL; Zadina, JE1
Bocheva, A; Dzambazova-Maximova, E1

Other Studies

6 other study(ies) available for tyrosyl-prolyl-tryptophyl-glycinamide and morphine

ArticleYear
Cyclic analogues of Tyr-W-MIF-1 with prolonged analgesic activity and potency comparable to DAMGO and morphine.
    Peptides, 1994, Volume: 15, Issue:8

    Topics: Analgesia; Analgesics; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Pain; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Time Factors

1994
Analgesic effects of Tyr-W-MIF-1: a mixed mu2-opioid receptor agonist/mu1-opioid receptor antagonist.
    European journal of pharmacology, 1996, Nov-28, Volume: 316, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Narcotics; Pain Measurement; Receptors, Opioid, mu

1996
Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Culture Media; Down-Regulation; Endorphins; Enkephalin, Methionine; Humans; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation

1998
Tyr-W-MIF-1-induced conditioned place preference.
    Peptides, 1999, Volume: 20, Issue:4

    Topics: Animals; Choice Behavior; Conditioning, Psychological; Injections, Intraventricular; Male; Morphine; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1999
Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia.
    Peptides, 1999, Volume: 20, Issue:8

    Topics: Animals; Drug Tolerance; Male; Morphine; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley

1999
Antiopioid properties of the TYR-MIF-1 family.
    Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:9

    Topics: Animals; Hindlimb; Immobilization; Morphine; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Tail; Time Factors

2004
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