tifluadom and morphine
tifluadom has been researched along with morphine in 25 studies
Compound Research Comparison
| Studies (tifluadom) | Trials (tifluadom) | Recent Studies (post-2010) (tifluadom) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 78 | 0 | 0 | 44,270 | 5,200 | 8,695 |
Protein Interaction Comparison
| Protein | Taxonomy | tifluadom (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (72.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N | 1 |
| Craft, RM; Dykstra, LA | 2 |
| Dong, XW; Headley, PM; Parsons, CG | 1 |
| Muraki, T; Nomoto, T; Oike, N; Shibata, Y | 1 |
| Dykstra, LA; Negus, SS; Picker, MJ | 1 |
| Gericke, M; Morgenstern, R; Ott, T | 1 |
| Bhargava, HN; Ramarao, P | 1 |
| Doty, P; Dykstra, LA; Picker, MJ | 1 |
| Jackson, HC; Kitchen, I | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Frey, HH | 1 |
| Bhargava, HN; Jablonski, HI; Ramarao, P; Rehder, KR | 1 |
| Cooper, SJ; Jackson, A; Kirkham, TC | 1 |
| Schmauss, C | 1 |
| Bueno, L; Fioramonti, J; Gué, M; Junien, JL | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Shearman, GT; Zeugner, H | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Cooper, SJ; Jackson, A | 1 |
| Benton, D; Brain, PF; Smoothy, R | 1 |
| Dykstra, LA; Gmerek, DE; Woods, JH | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Leander, JD | 1 |
| Burkard, WP; Flück, N; Müller, PM | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Zeugner, H | 1 |
Reviews
1 review(s) available for tifluadom and morphine
| Article | Year |
|---|---|
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response | 1985 |
Other Studies
24 other study(ies) available for tifluadom and morphine
| Article | Year |
|---|---|
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.
Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa | 2010 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors | 1992 |
Effects of intravenous mu and kappa opioid receptor agonists on sensory responses of convergent neurones in the dorsal horn of spinalized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Fentanyl; Hot Temperature; Male; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Physical Stimulation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Analgesic effect of mu- and kappa-opioid agonists in beige and CXBK mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Acetic Acid; Analgesics; Animals; Benzodiazepines; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Pentobarbital; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
The influence of tifluadom on cholecystokinin-induced antinociception.
Topics: Analgesics; Animals; Benzodiazepines; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine | 1990 |
Effects of kappa-opioid receptor agonists and morphine on food intake and urinary output in food-deprived and nondeprived rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Dose-Response Relationship, Drug; Feeding Behavior; Food Deprivation; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors; Urination | 1989 |
Differential cross-tolerance to opioid agonists in morphine-tolerant squirrel monkeys responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Food; Male; Morphine; Narcotics; Pentobarbital; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Saimiri | 1989 |
Effects of opioid agonists on urine production in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Benzodiazepines; Body Weight; Female; Male; Morphine; Naltrexone; Narcotics; Phentolamine; Pyrrolidines; Rats; Rats, Inbred Strains; Urodynamics | 1989 |
Mu antagonist properties of kappa agonists in a model of rat urinary bladder motility in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Cyclazocine; Ethylketocyclazocine; Female; Morphine; Morphine Derivatives; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1987 |
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1988 |
Effect of kappa-opioid receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Morphine; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Tail | 1988 |
Spinal kappa-opioid receptor-mediated antinociception is stimulus-specific.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Dynorphins; Ethylketocyclazocine; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1987 |
Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Diuretics; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
The kappa opioid receptor and food intake.
Topics: Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Diprenorphine; Eating; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Time Factors | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Effects of kappa opiate agonists on palatable food consumption in non-deprived rats, with and without food preloads.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Eating; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Satiety Response | 1985 |
Comparisons of the influence of morphine sulphate, morphine-3-glucuronide and tifluadom on social encounters in mice.
Topics: Animals; Benzodiazepines; Fear; Female; Male; Mice; Morphine; Morphine Derivatives; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Social Behavior | 1985 |
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Endorphins; Ethylketocyclazocine; Macaca mulatta; Morphinans; Morphine; Narcotic Antagonists; Pentobarbital; Pyrrolidines; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1987 |
Opposite effects of kappa-opioid agonists on gastric emptying of liquids and solids in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Injections, Intravenous; Morphinans; Morphine; Naloxone; Pyrrolidines | 1988 |
Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist.
Topics: Animals; Benzodiazepines; Diuresis; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1984 |
Characteristics of 3H-tifluadom binding in guinea-pig brain membranes.
Topics: Animals; Benzodiazepines; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Receptors, Opioid | 1984 |
The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors.
Topics: Animals; Benzodiazepines; Butorphanol; Cyclazocine; Drinking Behavior; Ethylketocyclazocine; Feeding Behavior; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |